Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions  

作　　者：Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song 

机构地区：[1]Department of General Medicine,Qingdao Central Hospital,University of Health and Rehabilitation Sciences(Qingdao Central Medical Group),Qingdao 266042,Shandong Province,China [2]Department of Gastroenterology,Qingdao Central Hospital,University of Health and Rehabilitation Sciences(Qingdao Central Medical Group),Qingdao 266042,Shandong Province,China [3]Department of Medical Administration,Qingdao Central Hospital,University of Health and Rehabilitation Sciences(Qingdao Central Medical Group),Qingdao 266042,Shandong Province,China [4]Qingdao Medical College,Qingdao University,Qingdao 266042,Shandong Province,China [5]Department of Infectious Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《World Journal of Gastroenterology》2024年第14期1968-1981,共14页世界胃肠病学杂志（英文版）

摘　　要：Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver disease.However,the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies.Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic options.Pyroptosis,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular characteristics.Considering the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the disease.The study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic approaches.Nevertheless,further studies are necessary.

关 键 词：Nonalcoholic fatty liver disease Apoptosis NECROPTOSIS Cell death Diagnosis Treatment 

分 类 号：R575.5[医药卫生—消化系统]