Hepatocellular carcinoma and musculoskeletal system: A narrative literature review  

作　　者：Jelena Jadzic Danijela Djonic 

机构地区：[1]Center of Bone Biology,Faculty of Medicine,University of Belgrade,Belgrade 11000,Serbia

出　　处：《World Journal of Gastroenterology》2024年第15期2109-2117,共9页世界胃肠病学杂志（英文版）

基　　金：Supported by the Ministry of Science of the Republic of Serbia,No.451-03-1524/2023-04/18;the Science Fund of the Republic of Serbia(IDEAS Program),No.7749444,BoFraM Project.

摘　　要：Musculoskeletal alterations in hepatocellular carcinoma(HCC)are less common than liver-related complications.However,they can significantly impact the quality of life and overall prognosis of patients with HCC.The main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asym-ptomatic and unapparent during routine clinical evaluations.This narrative literature review aimed to provide a comprehensive overview of the contem-porary literature related to the changes in the musculoskeletal system in patients with HCC,focusing on its clinical implications and underlying etiopathogenetic mechanisms.Osteolytic bone metastases are the most common skeletal alterations associated with HCC,which could be associated with an increased risk of low-trauma bone fracture.Moreover,previous studies reported that osteopenia,sarcopenia,and myosteatosis are associated with poor clinical outcomes in patients with HCC.Even though low bone mineral density and sarcopenia are consistently reported as reliable predictors of pretransplantation and post-transplantation mortality in HCC patients,these complications are frequently overlooked in the clinical management of patients with HCC.Taken together,contemporary literature suggests that a multidisciplinary approach is essential for early recognition and clinical management of HCC-associated musculoskeletal alterations to improve patient prognosis.Further research into the mechanisms and treatment options for musculoskeletal complications is warranted to enhance our understanding and clinical management of this aspect of HCC.

关 键 词：Hepatocellular carcinoma OSTEOPENIA OSTEOPOROSIS SARCOPENIA Bone metastases Bone fragility 

分 类 号：R735.7[医药卫生—肿瘤]