Blastomas of the digestive system in adults:A review  

作　　者：Yu Liu Tony El Jabbour Jonathan Somma Yukihiro Nakanishi Saverio Ligato Hwajeong Lee Zhi-Yan Fu 

机构地区：[1]Department of Pathology,LSU Health Sciences Center School of Medicine,New Orleans,LA 70112,United States [2]Department of Pathology,Hartford HealthCare,Hartford,CT 06102,United States [3]Department of Pathology,Moffitt Cancer Center,Tampa,FL 33612,United States [4]Department of Pathology and Laboratory Medicine,Albany Medical Center,Albany,NY 12208,United States

出　　处：《World Journal of Gastrointestinal Surgery》2024年第4期1030-1042,共13页世界胃肠外科杂志（英文版）（电子版）

摘　　要：Blastomas,characterized by a mixture of mesenchymal,epithelial,and undifferentiated blastematous components,are rare malignant neoplasms originating from precursor blast cells.This review focuses on digestive system blastomas in adult patients,including gastroblastoma,hepatoblastoma,and pancreatoblastoma.Gastroblastoma is a biphasic,epitheliomesenchymal tumor,with only sixteen cases reported to date.In addition to the characteristic histology,metastasisassociated lung adenocarcinoma transcript 1-glioma-associated oncogene homolog 1 gene fusion is typical,although recently novel ewing sarcoma breakpoint region 1-c-terminal binding protein 1 and patched 1-glioma-associated oncogene homolog 2 fusions have been described.Hepatoblastoma is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic difficulty.Pancreatoblastoma,primarily a pediatric tumor,displays acinar differentiation and squamoid nests with other lines of differentiation also present,especially neuroendocrine.Diagnostic approaches for these blastomas include a combination of imaging modalities,histopathological examination,and molecular profiling.The treatment generally involves surgical resection,which may be supplemented by chemotherapy or radiotherapy in some cases.Prognoses vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes,particularly in the setting of metastases.This review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.

关 键 词：Adult blastomas Gastroblastoma HEPATOBLASTOMA PANCREATOBLASTOMA Digestive system 

分 类 号：R735.37[医药卫生—肿瘤]