A medium chain fatty acid, 6-hydroxyhexanoic acid (6-HHA), protects against obesity and insulin resistance  

作　　者：Sara C.Sebag Meihua Hao Qingwen Qian Chawin Upara Qiong Ding Min Zhu Jeffrey A.Banas Huojun Cao Liu Hong Ling Yang 

机构地区：[1]Department of Anatomy and Cell Biology,University of Iowa Carver College of Medicine,Iowa City,IA 52242,USA [2]Fraternal Order of Eagles Diabetes Research Center,University of Iowa Carver College of Medicine,Iowa City,IA 52242,USA [3]Pappajohn Biomedical Institute,University of Iowa Carver College of Medicine,Iowa City,IA 52242,USA [4]Iowa Institute for Oral Health Research,University of Iowa College of Dentistry,Iowa City,IA 52242,USA

出　　处：《Acta Pharmaceutica Sinica B》2024年第4期1892-1894,共3页药学学报（英文版）

基　　金：Ling Yang is supported by R01DK108835 and R01DK126817(USA),and Sara C.Sebag and Liu Hong are supported by R01DE026433(USA).

摘　　要：To the Editor,Obesity,one of the most serious health concerns worldwide,exacerbates periodontitis pathogenesis and reduces the effectiveness of treatments1.Conversely,periodontitis-associated inflammation disrupts systemic lipid and glucose homeostasis,the major risk factors for developing obesity-associated pathologies1.Accumulated studies have demonstrated that certain supplemental dietary lipids such as dietary polyunsaturated fatty acids,have beneficial outcomes for diabetic and obese patients.In addition to dietary lipid supply,the oral and gut microbiota produce fatty acids(FAs)which provide the host with essential nutrients and aid in defense against pathogens.Hydroxyhexanoic medium chain FAs(MCFAs;6–12 carbons)are bacterial-derived lipids shown to have anti-inflammatory and insulin sensitization effects in diverse cell types such as hepatocytes2.However,whether and to what extent oral microbiota-produced MCFAs may ameliorate obesity-associated metabolic dysfunction are largely unknown.

关 键 词：OBESITY dietary LIPIDS 

分 类 号：R575[医药卫生—消化系统]