Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress  

作　　者：Shengduo Pei Jonas Sjölund Yueyun Pan Kristian Pietras Mikael C.I.Karlsson 

机构地区：[1]Department of Microbiology,Tumor and Cell Biology,Karolinska Institutet,Stockholm,Sweden [2]Division of Translational Cancer Research,Department of Laboratory Medicine,Lund University Cancer Centre,Lund University,Lund,Sweden

出　　处：《Cellular & Molecular Immunology》2024年第1期91-94,共4页中国免疫学杂志（英文版）

基　　金：supported by the Swedish Research council and the Swedish cancer foundation.

摘　　要：Invariant natural killer T(iNKT)cells are part of the family of unconventional T cells,and they recognize glycolipid antigens presented on the MHC class I like molecule CD1^([1]).In humans there are five CD1 molecules named CD1a to CD1e,whereas mice use only CD1d for lipid presentation.Functionally,iNKT cells can elicit both cytotoxicity similarly to conventional CD8 T cells and secrete cytokines that influence the adaptive immune response including providing direct T cell help to B cells^([2]).In the context of tumors,they can use both release of granzyme B and use Fas-mediated mechanisms for killing of tumor cells.As iNKT cells use a restricted TCR repertoire and CD1 molecules are non-heterogenous the risk of graft vs host disease is limited and thus these T cells have been an attractive option for off the shelf immunotherapy to treat cancer^([3]).

关 键 词：KILLER CD1D CANCER 

分 类 号：R392[医药卫生—免疫学]