WNT5A Regulated by miR154-5p is Associated with Angiopoiesis and Invasion of Placental Site Trophoblastic Tumor (PSTT)  

作　　者：ZHANG Sai CHEN Zhi Xian ZHANG Mo DU Yan ZHOU Jia Yi WU Jing YU Yin Hua CAO Qi ZHAO Hong Bo 

机构地区：[1]Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China

出　　处：《Biomedical and Environmental Sciences》2024年第4期423-427,共5页生物医学与环境科学（英文版）

基　　金：supported by grants from Shanghai Municipal Commission of Health and Family Planning[grant number:20234Y0067];the National Natural Science Foundation of China[No:81971394,82371687].

摘　　要：Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.

关 键 词：CHEMOTHERAPY DIAGNOSIS METASTASIS 

分 类 号：R737.3[医药卫生—肿瘤]