VILIP-1在谷氨酸诱导的神经兴奋性毒性中的作用研究进展  

VILIP-1 in Glutamate-mediated Neuroexcitotoxicity:a Systematic Review

作　　者：董瑶 于福平 DONG Yao;YU Fu-ping(Department of Anesthesiology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院麻醉科,南昌330006

出　　处：《实用临床医学（江西）》2024年第2期129-134,共6页Practical Clinical Medicine

摘　　要：谷氨酸引起的神经兴奋毒性与多种神经退行性疾病如帕金森病(PD)和阿尔茨海默病(AD)的发病机制有关。神经兴奋性毒性是指过量的谷氨酸过度激活N-甲基-D-天门冬氨酸(NMDA)受体(NMDAR)并导致神经元毒性的过程。视锥蛋白样蛋白1(VILIP-1)是神经元钙传感器(NCS)大家族的一员,主要在大脑神经元中表达,具有多种功能,包括调节神经元离子通道、神经元生长和存活。VILIP-1可以作为AD等神经退行性疾病的新兴指标。文章对VILIP-1在谷氨酸诱导的神经兴奋性毒性中的作用进行综述。Objective Glutamate-induced neuroexcitotoxicity has been implicated in the pathogenesis of several neurodegenerative diseases,including Parkinson’s disease(PD)and Alzheimer’s disease.Neuroexcitotoxicity occurs when excess glutamate overactivates the N-methyl-D-aspartate(NMDA)receptor(NMDAR),leading to neuronal toxicity.Visinin-like protein-1(VILIP-1)is a member of the large family of neuronal calcium sensors(NCS),which are mainly expressed in brain neurons and have multiple functions,including regulation of neuronal ion channels,neuronal growth and survival.Recent studies have revealed that VILIP-1 may serve as an emerging indicator of neurodegenerative diseases such as AD.This article provides a review of the mechanistic studies related to VILIP-1 in glutamate-mediated neuroexcitotoxicity.

关 键 词：视锥蛋白样蛋白1 神经兴奋性毒性 谷氨酸 NMDA 神经退行性疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]