Decoding Golgiphagy:selective recycling under stress  

作　　者：Alexis González Ivan Dikić 

机构地区：[1]Institute of Biochemistry II,Faculty of Medicine,Goethe University Frankfurt,Theodor-Stern-Kai 7,60590 Frankfurt am Main,Germany [2]Buchmann Institute for Molecular Life Sciences,Goethe University Frankfurt,Max-von-Laue Straße 15,60438 Frankfurt am Main,Germany [3]Frankfurt am Main,Germany.3Fraunhofer Institute of Translational Medicine and Pharmacology,Carl-von-Noorden-Platz 9,60596 Frankfurt am Main,Germany

出　　处：《Cell Research》2024年第4期277-278,共2页细胞研究（英文版）

摘　　要：In a recent study,Hickey et al.use quantitative proteomics to show that ER-phagy and Golgiphagy are preferentially activated during nutrient stress,and that YIPF3 and YIPF4 function as Golgiphagy receptors.Macroautophagy(hereby referred to as autophagy)is an important lysosomal degradation mechanism for organelles and macromolecules.Mammalian cells activate autophagy in response to nutrient stress,such as amino acid deficiency,to remodel the proteome according to cellular needs and recycle biosynthetic units.1 This process is often considered non-selective regarding the cellular components that are sequestered by autophagosomes.On the other hand,protein misfolding,damaged membrane-bound organelles,protein aggregation or bacterial infection can stimulate selective autophagy pathways,which rely on autophagy receptors to selectively couple cargo to the autophagosomal membrane.2 Several recent studies have raised the hypothesis that cells induce selective autophagy of the endoplasmic reticulum(ER-phagy)to alleviate nutrient stress.3 Hickey et al.4 address this question using a smart quantitative proteomics strategy and present an extensive profile of autophagic cargoes upon nutrient starvation,revealing that endoplasmic reticulum(ER)and also the Golgi complex are priority targets for cellular recycling.This implicates that ER-phagy and now Golgiphagy play a major role in cell adaptation to nutrient stress.The authors also identified the transmembrane proteins YIPF3 and YIPF4 as bona fide Golgiphagy receptors(Fig.1).

关 键 词：AGGREGATION HYPOTHESIS raised 

分 类 号：O62[理学—有机化学]