共价有机框架材料固定化酶的研究进展  

Recent Progress on Covalent Organic Frameworks Materials in Immobilized Enzymes

作　　者：金静 张羽飞 郑冬云[1] 郑明明[2] JIN Jing;ZHANG Yu-fei;ZHENG Dong-yun;ZHENG Ming-ming(College of Biomedical Engineering,South-Central Minzu University,Wuhan,430000,China;Oil Crops Research Institute of Chinese Academy of Agricultural Sciences,Wuhan,430000,China)

机构地区：[1]中南民族大学生物医学工程学院,湖北武汉430000 [2]中国农业科学院油料作物研究所,湖北武汉430000

出　　处：《分子催化（中英文）》2024年第2期171-186,I0005,共17页Journal of Molecular Catalysis(China)

基　　金：国家自然科学基金项目(32272271,31972038);国家重点基础研究发展计划(2021YFD2100303);湖北省自然科学基金(2021CFB209)。

摘　　要：共价有机框架(Covalent Organic Frameworks, COFs)是一种新型的多孔材料,具有结构规整、骨架稳定、孔径结构可调等特点,被视为固定化酶的理想载体.我们综述了近10年来COFs材料作为载体,通过物理吸附、共价连接、包埋的固定化策略制备固定化酶的研究进展与应用,并讨论了COFs材料在酶固定化领域所面临的机遇和挑战.Covalent Organic Frameworks(COFs)are a class of crystalline porous polymers that are constructed based on the interactions of different atoms via covalent bonds.Due to their adjustable physicochemical properties,structural regularity,robust framework,adjustable porosity and excellent absorptivity,COFs have been widely used to prepare immobilized enzymes for food processing,chemical production and wastewater treatment,etc.This paper reviews the advances in using COFs as the carriers for enzyme immobilization through different immobilization methods including physical adsorption,covalent linkage,and entrapment in recent 10 years.And discussed the remaining challenges as well as the forthcoming chances of COFs materials for enzyme immobilization.

关 键 词：共价有机框架 固定化酶 物理吸附 共价连接 包埋 

分 类 号：O643.36[理学—物理化学]