Compartmentalized regulation of organelle integrity in neurodegenerative diseases:lessons from the Drosophila motor neuron  

作　　者：Hyun Sung 

机构地区：[1]Department of Neurology,Johns Hopkins University School of Medicine,Baltimore,MD,USA [2]Medical Research Institute,and Department of Pharmacology,Pusan National University School of Medicine,Yangsan,Republic of Korea

出　　处：《Neural Regeneration Research》2025年第1期195-196,共2页中国神经再生研究（英文版）

基　　金：supported by the Merkin PNNR Center(23-DF/C2/261)(to HS).

摘　　要：Neurons are highly polarized,morphologically asymmetric,and functionally compartmentalized cells that contain long axons extending from the cell body.For this reason,their maintenance relies on spatiotemporal regulation of organelle distribution between the somatodendritic and axonal domains.Although some organelles,such as mitochondria and smooth endoplasmic reticulum,are widely distributed throughout the neuron,others are segregated to either the somatodendritic or axonal compartment.For example,Golgi outposts and acidified lysosomes are predominantly present in the somatodendritic domain and rarely distributed along the axon,whereas newly formed autophagosomes and synaptic vesicles are mainly distributed in the distal axon(Britt et al.,2016).

关 键 词：ORGANELLE REGULATION DISTRIBUTION 

分 类 号：R741[医药卫生—神经病学与精神病学]