大概念教学视角下“蛋白质工程的原理和应用”教学设计  

Teaching design for“principles and applications of protein engineering”from the perspective of big ideas teaching

作　　者：王坤[1] 谢建华 陈欣[1] WANG Kun;XIE Jianhua;CHEN Xin(Guangzhou No.6 Middle School,Guangzhou 510300,China)

机构地区：[1]广东省广州市第六中学,广州510300

出　　处：《生物学教学》2024年第4期28-32,共5页Biology Teaching

基　　金：广东省2021年度中小学教师培训中心科研课题“基于核心素养的高中生物学大概念教学策略研究”,No.GDP-2021-G006;广州市教育研究院2021年度科研课题“基于核心素养的高中生物学大概念教学设计研究”,No.21BJXP2121;广州市教育研究院2020年度教育政策研究课题“基于教研医区域合作和STS教育理念的高中生物‘健康生活’校本课程实践研究”,No.ZCYJ20002。

摘　　要：以“转基因抗虫棉的培育和应用”情境贯穿大概念“基因工程赋予生物新的遗传特性”的学习,在“蛋白质工程的原理和应用”一节的教学中,以“改造Bt蛋白,增强杀虫效果”为主要任务,引导学生在解决问题的过程中,深刻理解蛋白质分子结构与功能的关系,初步建构蛋白质工程的概念,同时应用概念尝试设计抗新冠病毒药物蛋白,发展完善概念,以达到对蛋白质工程概念的深度学习以及结构与功能观、生命信息观的培养。In the context of“cultivation and application of transgenic insect-resistant cotton”,the overarching concept of“genetic engineering endowing organisms with new genetic traits”is integrated into the learning experience.Within the section addressing“Principles and Applications of Protein Engineering”,the main task is centered on“modifying Bt protein to enhance insecticidal effects”.This approach guides students to deeply understand the relationship between protein molecular structure and function in the process of problem-solving while laying the groundwork for their understanding of protein engineering.Moreover,these concepts are applied to attempt the design of antiviral protein for COVID 19,deepening their insights and nurturing a holistic understanding of protein engineering,structural-function relationships,and the essence of biological information.

关 键 词：大概念教学 蛋白质工程 Bt蛋白改造 高中生物学 

分 类 号：G633.91[文化科学—教育学]