Overcoming the biofilm barrier by cell-like microbubbles for the treatment of biofilm-associated implant infections  

作　　者：Yan-Ling Hu Jin-Gai Jiang Hui-Juan Cheng Wei Shi Yan-Ni Song Min Zhang Dong-Liang Yang 

机构地区：[1]College of Life and Health,Nanjing Polytechnic Institute,Nanjing 210048,China [2]Hangzhou Huasu Industry Co.,Ltd.,Hangzhou 310012,China [3]Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM),School of Physical and Mathematical Sciences,Nanjing Tech University(NanjingTech),Nanjing 211816,China

出　　处：《Biomedical Engineering Communications》2024年第2期1-3,共3页生物医学工程通讯

基　　金：supported by the Natural Science Foundation of Jiangsu Province(BK20230117);the Natural Science Research Project of Nanjing Polytechnic Institute(NJPI-2023-04).

摘　　要：Although the advent of antibiotics has significantly improved the quality of life of infected patients,bacterial infections continue to pose a serious threat to public health[1,2].According to a recent report,within the next 30 years,bacterial infections are projected to surpass cancer in terms of lethality rates,resulting in an alarming 10 million deaths annually by 2050 due to the development of bacterial resistance[3].Moreover,the formation of bacterial biofilms hampers the penetration of antibacterial agents and inhibits the host immune response,making biofilm infections extremely challenging to treat[4-7].Hence,the development of innovative antimicrobial biofilm therapeutics is imperative.

关 键 词：INFECTIONS annually TREATMENT 

分 类 号：R73[医药卫生—肿瘤]