A new horizon for neuroscience:terahertz biotechnology in brain research  

作　　者：Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui 

机构地区：[1]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Department of Psychiatry,Kangci Hospital of Jiaxing,Tongxiang,Zhejiang Province,China [3]Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,China [4]Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Science,Shanghai,China [5]National Facility for Protein Science in Shanghai,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,China

出　　处：《Neural Regeneration Research》2025年第2期309-325,共17页中国神经再生研究（英文版）

基　　金：supported by grants from the National Key R&D Program of China,No.2017YFC0909200(to DC);the National Natural Science Foundation of China,No.62075225(to HZ);Zhejiang Provincial Medical Health Science and Technology Project,No.2023XY053(to ZP);Zhejiang Provincial Traditional Chinese Medical Science and Technology Project,No.2023ZL703(to ZP).

摘　　要：Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关 键 词：biological effect brain NEURON NEUROPSYCHIATRY NEUROSCIENCE non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology 

分 类 号：R741[医药卫生—神经病学与精神病学]