Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila  

作　　者：Jackson Powell Tobias Steinschaden Rose Horowitz Yuanquan Song 

机构地区：[1]Raymond G.Perelman Center for Cellular and Molecular Therapeutics,The Children’s Hospital of Philadelphia,Philadelphia,PA,USA [2]The Neuroscience Graduate Group,University of Pennsylvania,Philadelphia,PA,USA [3]Department of Pathology and Laboratory Medicine,University of Pennsylvania,Philadelphia,PA,USA [4]Medical University of Vienna,Center for Brain Research,Department of Neuroimmunology,Vienna,Austria

出　　处：《Neural Regeneration Research》2025年第2期475-476,共2页中国神经再生研究（英文版）

摘　　要：Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural regeneration.Both intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following injury.At the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to regenerate.Recent works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of regeneration.The role of glia in neuron regeneration has long been studied.

关 键 词：DEGENERATION FIRING SYSTEM 

分 类 号：R338[医药卫生—人体生理学]