Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family in physiological and pathophysiological process and diseases  

作　　者：Lu Qian Yanli Zhu Chao Deng Zhenxing Liang Junmin Chen Ying Chen Xue Wang Yanqing Liu Ye Tian Yang Yang 

机构地区：[1]Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases,Xi'an No.3 Hospital,The Affiliated Hospital of Northwest University,Northwest University,Xi'an 710021,China [2]Xi'an Key Laboratory of Innovative Drug Research for Heart Failure,Faculty of Life Sciences and Medicine,Northwest University,229 Taibai North Road,Xi'an 710069,China [3]Department of Cardiovascular Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,277 Yanta West Road,Xi'an 710061,China [4]Department of Cardiothoracic Surgery,The First Affiliated Hospital of Zhengzhou University,1 Jianshe East,Zhengzhou 450052,China [5]Department of Hematology,The First Affiliated Hospital of Xi'an JiaotongUniversity,277 Yanta West Road,Xi'an 710061,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第4期1249-1292,共44页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China (82360716,82070422,and 82200330);China Postdoctoral Science Foundation (2023T160526 and 2022M722571);Research Plan Project of Shaanxi Institute of Basic Science (22JHQ053);High-end Foreign Expert Introduction Program of National Science and Technology (G2022040014L);Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project (2022-QCYZH-036).

摘　　要：Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family(PGC-1s),consisting of three members encompassing PGC-1a,PGC-1β,and PGC-1-related coactivator(PRC),was discovered more than a quarter-century ago.PGC-1s are essential coordinators of many vital cellular events,including mitochondrial functions,oxidative stress,endoplasmic reticulum homeostasis,and inflammation.Accumulating evidence has shown that PGC-1s are implicated in many diseases,such as cancers,cardiac diseases and cardiovascular diseases,neurological disorders,kidney diseases,motor system diseases,and metabolic disorders.Examining the upstream modulators and co-activated partners of PGC-1s and identifying critical biological events modulated by downstream effectors of PGC-1s contribute to the presentation of the elaborate network of PGC-1s.Furthermore,discussing the correlation between PGC-1s and diseases as well as summarizing the therapy targeting PGC-1s helps make individualized and precise intervention methods.In this review,we summarize basic knowledge regarding the PGC-1s family as well as the molecular regulatory network,discuss the physio-pathological roles of PGc-1s in human diseases,review the application of PGC-1s,including the diagnostic and prognostic value of PGC-1s and several therapies in pre-clinical studies,and suggest several directions for future investigations.This review presents the immense potential of targeting PGC-1s in the treatment of diseases and hopefully facilitates the promotion of PGC-1s as new therapeutic targets.

关 键 词：DISEASES life PRECISE 

分 类 号：R363[医药卫生—病理学]