RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy  

作　　者：Wei-Wei Liu Si-Qing Zheng Tian Li Yun-Fei Fei Chen Wang Shuang Zhang Fei Wang Guan-Min Jiang Hao Wang 

机构地区：[1]Department of Laboratory Medicine,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China [2]School of Clinical Medicine,Shandong University,Jinan,China [3]Core Unit of National Clinical Research Center for Laboratory Medicine,Hefei,China [4]Neurosurgical Department,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China [5]Department of Clinical Laboratory,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第4期1565-1594,共30页信号转导与靶向治疗（英文）

基　　金：supported by the Scientific Research Project of Anhui Provincial Education Department (2022AH020079);the Natural Science Foundation of Anhui Province (2008085MH241).

摘　　要：Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells.Relevant studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of therapeutics.As a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular phenotypes.To be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological contexts.In this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied types.Then regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial metabolism.And we highlight the regulation of RNA modifications on immunometabolism,further influencing immune responses.Above all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNAtargeted therapeutics.Eventually,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

关 键 词：METABOLISM TARGETED alterations 

分 类 号：R730.51[医药卫生—肿瘤]