Analysis of the optimal target node to reduce seizure-like discharge in networks  

作　　者：闫璐瑶 张红慧 孙中奎 Luyao Yan;Honghui Zhang;Zhongkui Sun(School of Mathematics and Statistics,Northwestern Polytechnical University,Xi'an 710129,China;MIIT Key Laboratory of Dynamics and Control of Complex Systems,Xi'an 710129,China)

机构地区：[1]School of Mathematics and Statistics,Northwestern Polytechnical University,Xi'an 710129,China [2]MIIT Key Laboratory of Dynamics and Control of Complex Systems,Xi'an 710129,China

出　　处：《Chinese Physics B》2024年第5期712-720,共9页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(Grant Nos.12072265,12272295,and 11972288)。

摘　　要：Network approaches have been widely accepted to guide surgical strategy and predict outcome for epilepsy treatment.This study starts with a single oscillator to explore brain activity,using a phenomenological model capable of describing healthy and epileptic states.The ictal number of seizures decreases or remains unchanged with increasing the speed of oscillator excitability and in each seizure,there is an increasing tendency for ictal duration with respect to the speed.The underlying reason is that the strong excitability speed is conducive to reduce transition behaviors between two attractor basins.Moreover,the selection of the optimal removal node is estimated by an indicator proposed in this study.Results show that when the indicator is less than the threshold,removing the driving node is more possible to reduce seizures significantly,while the indicator exceeds the threshold,the epileptic node could be the removal one.Furthermore,the driving node is such a potential target that stimulating it is obviously effective in suppressing seizure-like activity compared to other nodes,and the propensity of seizures can be reduced 60%with the increased stimulus strength.Our results could provide new therapeutic ideas for epilepsy surgery and neuromodulation.

关 键 词：EPILEPSY driving node epileptic node seizure regulation 

分 类 号：O157.5[理学—数学] R742.1[理学—基础数学]