Role of copper chelating agents: between old applications and new perspectives in neuroscience  

作　　者：Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese 

机构地区：[1]Department of Pharmacy-Pharmaceutical Science,University of Bari Aldo Moro,Bari,Italy [2]Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J),Section of Veterinary Science and Animal Production,University of Bari Aldo Moro,Bari,Italy [3]Department of Engineering Management in Biotechnology,Faculty of Economics and Engineering Management in Novi Sad,University Business Academy in Novi Sad,Novi Sad,Serbia

出　　处：《Neural Regeneration Research》2025年第3期751-762,共12页中国神经再生研究（英文版）

摘　　要：The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关 键 词：agriculture Alzheimer's disease CHELATORS COPPER feed supplements MULTI-TARGET 

分 类 号：R96[医药卫生—药理学]