MULTI-TARGET

作品数：133被引量：304H指数：8
导出分析报告
相关领域：自动化与计算机技术更多>>
相关作者：胡莹杨雁芳杨文志张英涛杨国胜更多>>
相关机构：西南大学北京大学中国科学院北京理工大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国航空科学基金国家高技术研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Covalent multi-targeted radiopharmaceuticals for enhanced tumor theranostics
《Science China Chemistry》2025年第4期1456-1467,共12页Yirui Guo Zhengzhong Lv Yuqi Zhang Zhongsheng Zhao Yurong Fan Yan Chen Miao Li Xingxiang Ren Yiming Feng Zhixin Han Hongyuan Wen Guohua Fan Ru Yang Haibin Shi 
supported by the National Natural Science Foundation of China(T2325019,22077092);the Basic Research Program of Jiangsu(BK20243030);the Special Project of“Technological Innovation”Project of CNNC Medical Industry Co.Ltd.(ZHYLYB2021001);the Four“Batches"Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(2022XM19);the Open Project Program of the State Key Laboratory of Radiation Medicine and Protection(GZK12024016,GZK12023050,GZK12024013);a Project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Tumor-targeted radiopharmaceuticals have become an attractive modality for tumor diagnosis and treatment in clinics.However;their wide clinical applications are seriously impeded by poor tumor targeting;rapid systemic...
关键词：covalent targeted radiopharmaceuticals sulfenated protein nuclear imaging lung cancer THERANOSTICS 
Multi-target inhibition property of Persicaria hydropiper phytochemicals against gram-positive and gram-negative bacteria via molecular docking,dynamics simulation,and ADMET analysis
《Digital Chinese Medicine》2025年第1期76-89,共14页Golak Majumdar Shyamapada Mandal 
Research Grants of Senior Research Fellowship in favor of first author(Gloak Majumdar)from Council of Scientific and Industrial Research(CSIR,New Delhi,Government of India)(CSIR-SRF)with Award No.09/1151/(0008)2020-EMR-I.
Objective To evaluate the antibacterial potential of bioactive compounds from Persicaria hydropiper(L.)(P.hydropiper)against bacterial virulence proteins through molecular docking(MD)and experimental validation.Method...
关键词：Persicaria hydropiper phytochemicals Molecular docking Molecular dynamics simulation Bacterial pathogenicity-related proteins PHARMACOKINETICS 
From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target
《World Journal of Diabetes》2025年第3期273-276,共4页Jian Yang Cheng-Zhi Zhang Jing Zhang 
Supported by National Natural Science Foundation of China,No.82471616,No.82170418,and No.82271618;Natural Science Foundation of Hubei Province,No.2022CFA015;Central Guiding Local Science and Technology Development Project,No.2022BGE237;Key Research and Development Program of Hubei Province,No.2022BCE001,and No.2023BCB139;Hubei Provincial Health Commission Project,No.WJ2023M151。
We are deeply interested in the recent findings onβ-arrestin 2.Liu et al demonstrated thatβ-arrestin 2 knockout provides significant protection in diabetic nephropathy,underscoring its potential as a promising thera...
关键词：Type 2 diabetes Diabetic nephropathy β-arrestin 2 β-arrestin 1 Metabolic regulation Tissue-specific signaling Therapeutic strategies Multi-target therapies 
Role of copper chelating agents: between old applications and new perspectives in neuroscience
《Neural Regeneration Research》2025年第3期751-762,共12页Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese 
The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays a...
关键词：agriculture Alzheimer's disease CHELATORS COPPER feed supplements MULTI-TARGET 
Current development and future prospects of multi-target assignment problem:A bibliometric analysis review
《Defence Technology(防务技术)》2025年第1期44-59,共16页Shuangxi Liu Zehuai Lin Wei Huang Binbin Yan 
the financial support provided by the National Natural Science Foundation of China(NSFC)(Grant No.62173274);the National Key R&D Program of China(Grant No.2019YFA0405300);the Natural Science Foundation of Hunan Province of China(Grant No.2021JJ10045);the Practice and Innovation Funds for Graduate Students of Northwestern Polytechnical University(Grant No.PF2023046);the Open Research Subject of State Key Laboratory of Intelligent Game(Grant No.ZBKF-24-01);the Postdoctoral Fellowship Program of CPSF(No.GZB20240989);the China Postdoctoral Science Foundation(Grant No.2024M754304)。
The multi-target assignment(MTA)problem,a crucial challenge in command control,mission planning,and a fundamental research focus in military operations,has garnered significant attention over the years.Extensively stu...
关键词：Multi-target assignment Offensive and defensive confrontation Cooperative operation Modeling mechanism Solution algorithm CiteSpace analysis 
Network pharmacology, molecular docking, and untargeted metabolomics reveal molecular mechanisms of multi-targets effects of Qingfei Tongluo Plaster improving respiratory syncytial virus pneumonia
《Chinese Herbal Medicines》2024年第4期638-655,共18页Mengfei Yang Xiuying Zhang Qing Liu Yongxue Wang 
supported by the National Natural Science Foundation of China (No. 81973906)。
Objective: Qingfei Tongluo Plaster(QFP), an improved Chinese medicine hospital preparation, is an attractive treatment option due to its well clinical efficacy, convenience, economy, and patient compliance in the trea...
关键词：CHILDREN metabolomics network pharmacology PIK3/AKT pathway Qingfei Tongluo Plaster respiratory syncytial virus pneumonia 
ICPS multi-target constrained comprehensive security control based on DoS attacks energy grading detection and compensation
《Journal of Measurement Science and Instrumentation》2024年第4期518-531,共14页HAN Yinlong HAN Xiaowu 
supported by Gansu Higher Education Innovation Fund Project(No.2023B-439)。
Aiming at the industry cyber-physical system(ICPS)where Denial-of-Service(DoS)attacks and actuator failure coexist,the integrated security control problem of ICPS under multi-objective constraints was studied.First,fr...
关键词：industry cyber-physical system(ICPS) Denial-of-Service(DoS)attacks energy grading detection security event triggering mechanism time series analysis methods cone complementary linearization 
Near-field joint estimation of multi-targets’position and velocity in a terahertz MIMO-OFDM system based on tensor decomposition
《Frontiers of Information Technology & Electronic Engineering》2024年第12期1708-1722,共15页Ke LIU Shengfu ZHAO Weixin CHEN Zhen WANG Lingxiang LI Zhi CHEN Qiang XU 
Project supported by the National Natural Science Foundation of China(Nos.62271121 and 62301465)。
This paper investigates the joint estimation of multi-targets’position and velocity for a terahertz multi-input multi-output(MIMO)orthogonal frequency division multiplexing(OFDM)system operating in the near field bas...
关键词：TERAHERTZ Multi-input multi-output orthogonal frequency division multiplexing(MIMO-OFDM) Near-field localization(NFL) Velocity estimation Tensor decomposition 
Present and prospect of transarterial chemoembolization combined with tyrosine kinase inhibitor and PD-1 inhibitor for unresectable hepatocellular carcinoma被引量：1
《World Journal of Gastrointestinal Oncology》2024年第11期4315-4320,共6页Rui Zhang Yan-Hui Liu Yu Li Nan-Nan Li Zheng Li 
The National Natural Science Foundation of China,No.82104525;The Natural Science Foundation of the Jiangsu Higher Education Institutions of China,No.21KJB360009.
In this editorial,we comment on the article(World J Gastrointest Oncol 2024;16:1236-1247),which is a retrospective study of transarterial chemoembolization(TACE)combined with multi-targeted tyrosine kinase inhibitor(T...
关键词：Transarterial chemoembolization Multi-targeted tyrosine kinase inhibitor Programmed cell death protein-1 inhibitor Unresectable hepatocellular carcinoma Mechanism 
Naringin and Naringenin:Potential Multi-Target Agents for Alzheimer’s Disease
《Current Medical Science》2024年第5期867-882,共16页Jing LU Jie CHEN Shu-yue LI Guang-jie PAN Yi OU Li-fu YUAN Jian-ping JIANG Ling-hui ZENG Jie ZHAO 
supported by the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.TGD23C050001);by National Natural Science Foundation of China(No.82074186).
Alzheimer’s disease(AD)is one of the most common forms of neurodegenerative dementia.The etiology of AD is multifactorial,and its complex pathophysiology involves tau and amyloid-βdeposition,increased oxidative stre...
关键词：Alzheimer’s disease NARINGIN NARINGENIN multitarget 
全选清除导出
共14页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部