肺癌微环境中肿瘤源性外泌体的通讯与免疫调节作用  

Communication and immune regulation of tumor-derived exosomes in the lung cancer microenvironment

作　　者：赖威 彭敦钰[2] 李晶[2] 李宁[1] 汪巍[1] Lai Wei;Peng Dunyu;Li Jing;Li Ning;Wang Wei(Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胸外科,武汉430060 [2]武汉大学人民医院麻醉科,武汉430060

出　　处：《中华实验外科杂志》2024年第4期881-884,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(82102269);湖北省自然科学省基金(2020CFB295);湖北省重点实验室开发项目(2021KFY052)。

摘　　要：肺癌是全球癌症死亡的主要原因,尽管目前在肺癌的早期诊断和治疗方面取得了一定进展,但总体生存率仍然很低。肺癌的发生是一个多因素作用的结果,包括肺癌细胞与其细胞微环境(免疫细胞)之间的相互作用。外泌体作为一种细胞外囊泡,在调节肿瘤生长、促进血管增殖、肿瘤侵袭和转移方面发挥着重要作用。肿瘤源性的外泌体(TEXs)包含了多种肿瘤相关的大分子物质,并可能通过影响免疫细胞功能从而促进肿瘤的增殖。因此,了解肺癌微环境中TEXs的通讯与免疫调节作用具有重大意义。本文结合目前的研究进展,针对TEXs对肺癌微环境中免疫细胞的调节作用展开了综述。Lung cancer is the leading cause of cancer deaths globally,and despite current advances in the early diagnosis and treatment of lung cancer,overall survival rates remain low.Lung cancer development is a multifactorial outcome,including interactions between lung cancer cells and their cellular microenvironment(immune cells).Exosomes,as a kind of extracellular vesicles,play an important role in regulating tumor growth,promoting vascular proliferation,tumor invasion and metastasis.Tumor-derived exosomes(TEXs)contain a variety of tumor-associated macromolecules and may promote tumor proliferation by affecting immune cell function.Therefore,it is of great significance to understand the communication and immunomodulatory role of TEXs in the microenvironment of lung cancer.In this paper,we review the regulatory effects of TEXs on lung cancer immune cells in light of current research progress.

关 键 词：外泌体 肺癌 免疫调节 细胞通讯 

分 类 号：R734.2[医药卫生—肿瘤]