含硒纳米材料在前列腺癌诊疗中的应用及其分子机制研究进展  

New treatment strategies for prostate cancer:Applications and molecular mechanisms of selenium-containing nanomaterials

作　　者：周致远 陈家浩 宋泓辰 杨博宇 ZHOU Zhiyuan;CHEN Jiahao;SONG Hongchen;YANG Boyu(Department of Urology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Neurosurgery,Gongli Hospital of Pudong New Area,Shanghai 200135,China;Department of Urology,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China)

机构地区：[1]首都医科大学附属北京友谊医院泌尿外科,北京100050 [2]上海市浦东新区公利医院神经外科,上海200135 [3]上海交通大学附属第一人民医院泌尿外科,上海200080

出　　处：《中华肿瘤防治杂志》2024年第5期312-318,共7页Chinese Journal of Cancer Prevention and Treatment

基　　金：首都医科大学临床专科学院(系)培养基金开放课题(CCMU2022ZKYXY019)。

摘　　要：目的对含硒纳米材料在前列腺癌诊疗中的研究进展进行综述分析,为其临床应用提供参考思路。方法以“硒、纳米硒、前列腺癌”为关键词,检索PubMed和CNKI期刊全文数据库1970-01-01-2023-12-31发表的相关文献。纳入标准:(1)有硒或含硒纳米材料参与的临床研究;(2)包括前列腺癌化疗、放疗、靶向治疗等诊疗方式的研究。排除标准:排除重复、数据陈旧和存在争议的研究。最终纳入文献68篇。结果前列腺癌是中老年男性最常见的泌尿系统恶性肿瘤之一,开发治疗前列腺癌的新型药物始终是泌尿肿瘤方向研究的热点。甲基硒酸等传统形式的硒已被证明具有一定的抗氧化和抗肿瘤能力,但狭窄的治疗窗限制了其临床应用。近年来得益于纳米材料低毒性和高生物活性的优势,改良含硒纳米材料作为新型抗癌药物在医学领域得到广泛的重视和应用。结论含硒纳米材料在前列腺癌中的应用集中于检测与治疗两方面,相比传统形式的硒,其在前列腺癌化疗、放疗以及新型光热疗法等方面均具有一定的应用优势。本文总结了纳米硒在前列腺癌诊疗中的作用及其机制,以期为其在抗肿瘤领域的研究和应用提供思路。Objective To review and analyze the research progress of selenium-containing nanomaterials in the diagnosis and treatment of prostate cancer,and to provide ideas and references for its clinical application.Method With"selenium,nano-selenium,prostate cancer"as the key words,the relevant literatures published in PubMed and CNKI from 1970 to 2023 were searched.Inclusion criteria:(1)clinical studies involving selenium or selenium-containing nanomaterials;(2)including prostate cancer chemotherapy,radiotherapy,targeted therapy and other diagnosis and treatment methods.Exclusion criteria:Duplicate,outdated data and controversial studies were excluded.Finally,68 articles were included.Result Prostate cancer ranks prominently among the most prevalent malignancies of the urinary system in elderly males.The pursuit of innovative therapeutic agents for prostate cancer remains at the forefront of medical research.Traditional selenium derivatives,such as methylselenic acid,exhibit antioxidant and antitumoral capacities.However,their narrow therapeutic windows constrain their broader clinical utility.In recent years,the favorable toxicity profile and heightened bioactivity of nanomaterials have catalyzed the emergence of modified selenium-infused nanomaterials as prospective anticancer agents.Conclusion The application of selenium-containing nanomaterials in prostate cancer focuses on both detection and treatment.Compared with the traditional form of selenium,it has certain advantages in prostate cancer chemotherapy,radiotherapy and new photothermal therapy.This review elucidates the function and underlying mechanisms of nano-selenium in both the diagnosis and therapeutic management of prostate cancer,aiming to spur further research and deployment in oncology.

关 键 词：前列腺癌 纳米硒 氧化应激 硒化镉 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]