重视抑郁症认知损害对情感症状转归的影响  

Emphasizing the impact of cognitive impairment in depression on affective symptom outcomes

作　　者：朱荣鑫[1] 阎锐[1] 姚志剑[1] Zhu Rongxin;Yan Rui;Yao Zhijian(Department of Psychiatry,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院,南京210029

出　　处：《中华精神科杂志》2024年第5期257-260,共4页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(82271568,82301718);江苏精神疾病医学创新中心(CXZX202226);江苏省科技计划专项(BE2023667);江苏省自然科学基金(BK20231126,BK20230154);江苏省卫健委医学重点项目(ZD2021026)。

摘　　要：抑郁症患病率高且常导致严重的社会功能损害。抑郁症,尤其是青少年抑郁症的临床诊治困境仍是目前精神科临床实践面临的主要挑战。情感症状是目前抑郁症诊断的核心症状标准,但越来越多的研究证实了认知功能障碍也是抑郁症的核心症状之一,两者不仅均对抑郁症的临床表现和病程发展具有同样重要的地位,而且情感症状与认知功能损害间还存在着紧密而复杂的关联。探究抑郁症认知功能障碍和情感症状转归之间的关联及其病理机制的研究,对于指导临床评估、干预和改善整体预后至关重要。Depression has a high prevalence rate and often leads to severe social impairment.The dilemma of clinical diagnosis and treatment of major depressive disorder,especially in adolescents,is still a major challenge in psychiatric clinical practice.The affective symptoms serve as the primary symptom criteria for the diagnosis of major depressive disorder,but an increasing number of studies have proven that cognitive dysfunction is also one of the core symptoms of major depressive disorder.Both affective symptoms and cognitive impairment play an equally important role in the clinical manifestations and the progression.Moreover,there is a close and complex association between affective symptoms and cognitive impairment.The comprehension of the intricate interplay between cognitive dysfunction and emotional symptoms among patients with major depressive disorder is crucial for guiding clinical assessment,intervention,and overall prognosis improvement.

关 键 词：抑郁症 成人 青少年 认知损伤 情感症状 预后 

分 类 号：R749.4[医药卫生—神经病学与精神病学]