The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases  

作　　者：Ke-qi Fan Tao Huang Jian-shuai Yu Yi-yuan Li Jin Jin 

机构地区：[1]MOE Laboratory of Biosystem Homeostasis and Protection,and Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [2]Department of Gastroenterology,Sir Run Shaw Hospital,College of Medicine Zhejiang University,Hangzhou 310016,China [3]Key Laboratory for Developmental Genes and Human Disease,Ministry of Education,Institute of Life Sciences,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China

出　　处：《Fundamental Research》2024年第2期226-236,共11页自然科学基础研究（英文版）

基　　金：supported by distinguished Young Scientist Fund of NSFC(82125016);National Natural Science Foundation of China,Key Program(82230061);Zhejiang Provincial Natural Science Foundation of China(LR19C080001,LQ21H030013);supported by the National Key Research and Development Program of China(2018YFD0500100);the National Natural Science Foundation of China(81572651/81771675);the 111 Program(D20036).

摘　　要：According to a study from World Health Organization’s Global Burden of Disease,mental and neurological disorders have accounted for 13%of global diseases in recent years and are on the rise.Neuropsychiatric conditions or neuroinflammatory disorders are linked by the presence of an exaggerated immune response both peripherally and in the central nervous system(CNS).Cognitive dysfunction(CD)encompasses a complex group of diseases and has frequently been described in the field of autoimmune diseases,especially in multiple non-CNS-related autoimmune diseases.Recent studies have provided various hypotheses regarding the occurrence of cognitive impairment in autoimmune diseases,including that abnormally activated immune cells can disrupt the integrity of the blood-brain barrier(BBB)to trigger a central neuroinflammatory response.When the BBB is intact,autoantibodies and pro-inflammatory molecules in peripheral circulation can enter the brain to activate microglia,inducing CNS inflammation and CD.However,the mechanisms explaining the association between the immune system and neural function and their contribution to diseases are uncertain.In this review,we used clinical statistics to illustrate the correlation between CD and autoimmune diseases that do not directly affect the CNS,summarized the clinical features and mechanisms by which autoimmune diseases trigger cognitive impairment,and explored existing knowledge regarding the link between CD and autoimmune diseases from the perspective of the field of neuroimmunology.

关 键 词：Autoimmune diseases NEUROINFLAMMATION Central nervous system dysfunction AUTOANTIBODIES Inflammatory cytokines 

分 类 号：R741[医药卫生—神经病学与精神病学]