Allogenic microglia replacement:A novel therapeutic strategy for neurological disorders  

作　　者：Yanxia Rao Bo Peng 

机构地区：[1]Department of Laboratory Animal Science,MOE Frontiers Center for Brain Science,Fudan University,Shanghai 200032,China [2]Department of Neurosurgery,Huashan Hospital,Institute for Translational Brain Research,State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases,Fudan University,Shanghai 200000,China [3]Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu 226001,China

出　　处：《Fundamental Research》2024年第2期237-245,共9页自然科学基础研究（英文版）

基　　金：supported by STI2030-Major Projects(2022ZD0204700)(B.P.)and(2022ZD0207200)(Y.R.);National Natural Science Foundation of China(32170958)(B.P.)and(32000678)(Y.R.);Program of Shanghai Academic/Technology Research Leader(21XD1420400)(B.P.);Shanghai Pilot Program for Basic Research(21TQ014)(B.P.);“Shuguang Program”from Shanghai Education Development Foundation and Shanghai Municipal Education Commission(22SG07)(B.P.);Shanghai Municipal Science and Technology Major Project(B.P.);The Innovative Research Team of High-Level Local University in Shanghai(B.P.).

摘　　要：Microglia are resident immune cells in the central nervous system(CNS)that play vital roles in CNS development,homeostasis and disease pathogenesis.Genetic defects in microglia lead to microglial dysfunction,which in turn leads to neurological disorders.The correction of the specific genetic defects in microglia in these disorders can lead to therapeutic effects.Traditional genetic defect correction approaches are dependent on viral vectorbased genetic defect corrections.However,the viruses used in these approaches,including adeno-associated viruses,lentiviruses and retroviruses,do not primarily target microglia;therefore,viral vector-based genetic defect corrections are ineffective in microglia.Microglia replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy microglia.In this paper,we systematically review the history,rationale and therapeutic perspectives of microglia replacement,which would be a novel strategy for treating CNS disorders.

关 键 词：MICROGLIA REPLACEMENT Microglia replacement Microglia depletion Microglia-free niche CSF1R 

分 类 号：R741[医药卫生—神经病学与精神病学]