不同感觉功能对抑郁的影响及其神经机制  

The Effects of Different Sensory Functions on Depression and Its Neuromechanism

作　　者：刘文彬[1,2] 漆正堂 刘微娜[1,2] Liu Wenbin;Qi Zhengtang;Liu Weina

机构地区：[1]华东师范大学“青少年健康评价与运动干预”教育部重点实验室,上海2200241 [2]华东师范大学体育与健康学院

出　　处：《复印报刊资料（心理学）》2023年第8期42-58,共17页

基　　金：国家自然科学基金资助项目(31871208);上海市自然科学基金资助项目(18ZR1412000);中央高校基本科研业务费专项资金资助项目(40500-21203-542500/006/004);华东师范大学2021年优秀博士生学术创新能力提升计划项目(YBNLTS2021-022)。

摘　　要：大脑通过视觉、听觉、嗅觉、味觉和触觉等感官通道接收来自外界的信息。不同感觉功能受损涉及抑郁发生的中枢机制,而基于不同感官通道进行适当刺激以及多感官联合干预也可能发挥显著的抑郁治疗作用。笔者以症状一脑区一机制一治疗为逻辑主线,首次系统梳理了五种主要感觉障碍人群的抑郁临床症状、抑郁神经机制以及基于感觉刺激的抗抑郁治疗。结果表明,不同感觉功能障碍对抑郁相关神经机制的影响可能表征了不同的抑郁病理,涉及神经元电活动(某些神经元放电和神经环路激活等)和神经生化改变(神经可塑性和神经发生、炎症免疫和HPA轴、神经激素和神经递质等),且主要发生在边缘系统及其附近脑区,涉及岛叶、叶、额叶等。因此,未来研究可聚焦于机体对不同感觉信息的提取,这将为人类抑郁的病因和治疗提供新的研究视角。The brain receives information from the outside world through the visual,auditory,olfactory,taste,and tactile sensory channels.Dfferent sensory impairments are involved in the central mechanism of depression,and appropriate stimulation based on different sensory channels and multi-sensory combined interventions may also play a significant role in its treatment.Taking"symptoms-brain region-mechanism-treatment"as the logical thread,the author systematically reviewed the clinical symptoms of depression,the neural mechanisms of depres-sion,and the antidepressant treatments based on sensory stimulation for the first time in persons with five major sen-sory disorders.The results show that different sensory dysfunctions in the neural mechanisms related to depression may represent the different pathologies of depression,involving neuronal electrical activity(firing of certain neurons and activation of neural circuits,etc.)and neural biochemical changes(neuroplasticity and neurogenesis,inflamma-tory immunity and HPA axis,neurohormones and neurotransmtters,etc.);these mainly occur in the limbic system and its adjacent brain regions,which involve the insular lobe,temporal lobe,frontal lobe,etc.Therefore,future re-search should focus on the extraction of different sensory information,which will provide a new research perspective for the etiology and treatment of human depression.

关 键 词：视觉 听觉 嗅觉 味觉 触觉 抑郁 

分 类 号：R749.4[医药卫生—神经病学与精神病学]