Translocator protein and neurodegeneration: insights from Alzheimer’s disease  

作　　者：Arpit Kumar Pradhan Rainer Rupprecht Gerhard Rammes 

机构地区：[1]Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München,Klinikum rechts der Isar,Munich,Germany [2]Graduate School of Systemic Neurosciences,Ludwig-Maximilians-Universität München,Martinsried,Germany [3]Department of Psychiatry and Psychotherapy,University Regensburg,Regensburg,Germany

出　　处：《Neural Regeneration Research》2025年第4期1090-1091,共2页中国神经再生研究（英文版）

基　　金：supported by the German Research Foundation(Deutsche Forschungsgemeinschaft)(DFG),project number 422179811 to RR and RA 689/12-1 to GR.

摘　　要：The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce steroids.The main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关 键 词：CHOLESTEROL ORGANS 

分 类 号：R749.16[医药卫生—神经病学与精神病学]