Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?  

在线阅读下载全文

作  者:Danko Jeremic Lydia Jiménez-Díaz Juan D.Navarro-López 

机构地区:[1]NeuroPhysiology&Behavior Lab,University of Castilla-La Mancha,Biomedical Research Center(CRIB),School of Medicine of Ciudad Real,Ciudad Real,Spain

出  处:《Neural Regeneration Research》2025年第4期1092-1093,共2页中国神经再生研究(英文版)

基  金:supported by grants PID2020-115823-GB100 funded by MCIN/AEI/10.13039/501100011033;SBPLY/21/180501/000150 funded by JCCM/ERDF-A way of making Europe;2022-GRIN-34354 grant by UCLM/ERDF intramural funding to LJD;JDNL.DJ held a predoctoral fellowship granted by UCLM/ESF“Plan Propio de Investigación.”。

摘  要:Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the pathology.However,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one another.Some researchers argue that these proteins are mere executors rather than primary causes of pathology.Therefore,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early AD.Moreover,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关 键 词:AMYLOID ALZHEIMER additive 

分 类 号:R749.16[医药卫生—神经病学与精神病学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象