General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain  

作　　者：Wen-Xin Hang Yan-Chang Yang Yu-Han Hu Fu-Quan Fang Lang Wang Xing-Hua Qian Patrick M.McQuillan Hui Xiong Jian-Hang Leng Zhi-Yong Hu 

机构地区：[1]Department of Anesthesiology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China [2]Department of Cell Biology,Yale University,New Haven,CT 06520,USA [3]Department of Neurology of the First Affiliated Hospital,Interdisciplinary Institute of Neuroscience and Technology,School of Brain Science and Brain Medicine,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310027,China [4]Department of Anesthesiology,Jiaxing Maternity and Childcare Health Hospital,Jiaxing,Zhejiang 314009,China [5]Department of Anesthesiology,Penn State Hershey Medical Centre,Penn State College of Medicine,Hershey,PA 17033,USA [6]Department of Central Laboratory,Affiliated Hangzhou First People’s Hospital,Westlake University School of Medicine,Hangzhou,Zhejiang 310006,China

出　　处：《Zoological Research》2024年第3期691-703,共13页动物学研究（英文）

基　　金：supported by the Natural Science Foundation of Zhejiang Province(LZ22H090002,2014C33170);National Natural Science Foundation of China(82171260,81641042,81471240)。

摘　　要：General anesthetic agents can impact brain function through interactions with neurons and their effects on glial cells.Oligodendrocytes perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity regulation.They are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and apoptosis.Neurologists are increasingly interested in the effects of general anesthetic agents on oligodendrocytes.These agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and function.In this review,we summarize the effects of general anesthetic agents on oligodendrocytes.We anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关 键 词：OLIGODENDROCYTES General anesthetic agents NEUROTOXICITY Central nervous system Perioperative neurocognitive disorders 

分 类 号：R614[医药卫生—麻醉学]