The global regulation of c-di-GMP and cAMP in bacteria  

作　　者：Cong Liu Rui Shi Marcus S.Jensen Jingrong Zhu Jiawen Liu Xiaobo Liu Di Sun Weijie Liu 

机构地区：[1]Jiangsu Key Laboratory of Phylogenomics&Comparative Genomics,School of Life Sciences,Jiangsu Normal University,Xuzhou,China [2]Key Laboratory of Metabolic Engineering and Biosynthesis Technology,Ministry of Industry and Information Technology,Nanjing University of Science and Technology,Nanjing,China

出　　处：《mLife》2024年第1期42-56,共15页微生物（英文）

基　　金：funded by the National Natural Science Foundation of China(Nos.32370023,32370583,31970036,and 31900401);Natural Science Foundation of the Jiangsu Higher Education Institutions of China(20KJB180001 and 20KJA180007);Natural Science Foundation of Jiangsu Province(BK20210920 and BK20231350);Jiangsu Agricultural Science and Technology Innovation Fund(Cx223125);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：Nucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria.The best-studied examples are cyclic AMP(cAMP)and bis-(3'-5')-cyclic dimeric guanosine monophosphate(c-di-GMP),which both act as global regulators.Global regulatory frameworks of c-di-GMP and cAMP in bacteria show several parallels but also significant variances.In this review,we llustrate the global regulatory models of the two nucleotide second messengers,compare the different regulatory frameworks between c-di-GMP and cAMP,and discuss the mechanisms and physiological significance of cross-regulation between c-di-GMP and cAMP.c-di-GMP responds to numerous signals de-pendent on a great number of metabolic enzymes,and it regulates various signal transduction pathways through its huge number of effectors with varying activities.In contrast,due to the limited quantity,the cAMP metabolic enzymes and its major effector are regulated at different levels by diverse signals.cAMP performs its global regulatory function primarily by controlling the transcription of a large number of genes via cAMP receptor protein(CRP)in most bacteria.This review can help us understand how bacteria use the two typical nucleotide second messengers to effectively coordinate and integrate various physiological processes,providing theoretical guidelines for future research.

关 键 词：BACTERIA CAMP C-DI-GMP CROSS-REGULATION CRP 

分 类 号：Q93[生物学—微生物学]