Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis  

作　　者：Jie Wu Ying Zheng Li-Na Zhang Cai-Li Gu Wang-Li Chen Min-Qiang Chang 

机构地区：[1]Department of Respiratory and Oncology,72nd Group Army Hospital of PLA,Huzhou 313000,Zhejiang Province,China [2]Department of Otorhinolaryngology,72^(nd)Group Army Hospital of PLA,Huzhou 313000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第16期2704-2712,共9页世界临床病例杂志

摘　　要：Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases.Engineering specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019(COVID-19)infection.COVID-19 causes pulmonary embolisms,thus new therapeutic options are required to target thrombosis,as conventional treatment options are either not effective due to the complexity of the immunethrombosis pathophysiology.In this review,we discuss regulation of immune response in respiratory diseases especially COVID-19.We further discuss thrombosis and provide an overview of some antithrombotic nanoparticles,which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious diseases.We also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways,and thus can be recommended to treat respiratory infectious diseases.

关 键 词：NANOMEDICINES IMMUNOTHERAPEUTICS Respiratory diseases COVID-19 THROMBOSIS 

分 类 号：R511[医药卫生—内科学]