Treatment for paraganglioma with stereotactic radiotherapy  

作　　者：Antonio Pontoriero Paola Critelli Marco Zeppieri Filippo Flavio Angileri Tamara Ius 

机构地区：[1]Radiation Oncology Unit,Department of Biomedical,Dental Science and Morphological and Functional Images,University of Messina,Messina 98125,Italy [2]Department of Ophthalmology,University Hospital of Udine,Udine 33100,Italy [3]Neurosurgery Unit,Department of Biomedical,Dental Science and Morphological and Functional Images,University of Messina,Messina 98125,Italy [4]Neurosurgery Unit,Head-Neck and NeuroScience Department,University Hospital of Udine,Udine 33100,Italy

出　　处：《World Journal of Clinical Cases》2024年第16期2729-2737,共9页世界临床病例杂志

摘　　要：BACKGROUND Paragangliomas(PG)are rare neoplasms of neuroendocrine origin that tend to be highly vascularized,slow-growing,and usually sporadic.To date,common treatment options are surgical resection(SR),with or without radiation therapy(RT),and a watch-and-wait approach.AIM To evaluate the local control and effectiveness of exclusive fractionated stereotactic RT(FSRT)treatment in unresectable PG(uPG).METHODS We retrospectively evaluated patients with uPG(medically inoperable or refused SR)treated with FSRT with a Cyberknife System(Accuray Incorporated,Sunnyvale,California).Toxicity and initial efficacy were evaluated.RESULTS From May 2009 to January 2023,6 patients with a median age of 68(range 20-84)were treated with FSRT.The median delivered dose was 21 Gy(range 20-30 Gy)at a median isodose line of 75.5%(range 70%-76%)in 4 fractions(range 3-5 fractions).The median volume was 13.6 mL(range 12.4-65.24 mL).The median cumulative biological effective dose and equivalent dose in 2-Gy fractions were 70 Gy and 37.10 Gy respectively.Site of origin involved were the timpa-nojugular glomus(4/6),temporal bone,and cervical spine.In 1 of the 6 patients,the follow-up was insufficient;5 of 6 patients showed a 5-year overall survival and 5-year progression-free survival of 100%.We observed negligible toxicities during and after RT.The majority of patients showed stable symptoms during follow-up.Only 1 patient developed spine metastases.CONCLUSION Our preliminary results on this small cohort of patients suggest that FSRT could be an effective and safe alternative to SR.

关 键 词：Unresectable paraganglioma Fractionated stereotactic radiation therapy CYBERKNIFE NEUROSURGERY METASTASIS 

分 类 号：R730.55[医药卫生—肿瘤]