Clinicopathological analysis of EWSR1/FUS::NFATC2 rearranged sarcoma in the left forearm:A case report  

作　　者：Qiao-Ling Hu Chao Zeng 

机构地区：[1]Department of Pathology,The Eighth Affiliated Hospital of Sun Yatsen University,Shenzhen 518000,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2024年第16期2887-2893,共7页世界临床病例杂志

基　　金：Supported by The Shenzhen Science and Technology Program,No.JCYJ20220530144407017.

摘　　要：BACKGROUND We present a case of an EWSR1/FUS::NFATC2 rearranged sarcoma in the left forearm and analyze its clinicopathological and molecular features.CASE SUMMARY The patient is a 23-year-old woman.Microscopically,the tumor cells were medium-sized round cells arranged in small nests.The cytoplasm was clear,nuclei were relatively uniform,chromatin was dense,nucleoli were visible,and mitotic figures were rare.Immunohistochemically,the tumor cells were positive for Vimentin,INI-1,CD99,NKX2.2,CyclinD1,friend leukaemia virus integration 1,and NKX3.1.Next-generation sequencing revealed the presence of the EWSR1-NFATC2 fusion gene.EWSR1/FUS::NFATC2 rearranged sarcomas are rare and can easily be misdiagnosed.CONCLUSION Clinical imaging,immunohistochemistry,and molecular pathology should be considered to confirm the diagnosis.

关 键 词：EWSR1 NFATC2 SARCOMA FOREARM Case report 

分 类 号：R737.25[医药卫生—肿瘤]