Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature  

作　　者：Fei Chen Wei-Wei Li Juan-Fen Mo Min-Jie Chen Su-Hang Wang Shu-Ying Yang Zheng-Wei Song 

机构地区：[1]Department of Hepatobiliary Surgery,The Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,Zhejiang Province,China [2]Graduate School,Bengbu Medical College,Bengbu 233000,Anhui Province,China [3]The Key Laboratory,The Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,Zhejiang Province,China [4]Department of Pathology,The Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,Zhejiang Province,China [5]Department of Intensive Medicine,The Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,Zhejiang Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第5期1449-1460,共12页世界胃肠外科杂志（英文版）（电子版）

基　　金：Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2022KY1246;Science and Technology Bureau of Jiaxing City,No.2023AZ31002 and No.2022AZ10009.

摘　　要：BACKGROUND Neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are unclear.Herein,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare disease.CASE SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 months.Physical examination showed mild tenderness in the upper abdomen and a positive Courvoisier sign.Blood tests showed elevated liver transaminase and carbohydrate antigen 199 levels.Imaging examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during surgery.Pathology suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated adenocarcinoma.The patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after surgery.Gene sequencing methods were used to compare gene mutations in the two primary bile duct tumours.CONCLUSION The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.

关 键 词：Neuroendocrine carcinoma Mixed neuroendocrine-non-neuroendocrine neoplasm CHOLANGIOCARCINOMA Extrahepatic bile duct Case report 

分 类 号：R735.2[医药卫生—肿瘤]