In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity:Insights from national inpatient sample 2020  

作　　者：Sashwath Srikanth Vibhor Garg Lakshmi Subramanian Jyoti Verma Hansika Sharma Harroop Singh Klair Shrenil A Kavathia Jithin Kolli Teja Nikhil Sai Vasireddy Kumar Anmol Dhanush Kolli Shruti Sanjay Bodhankar Sobya Hashmi Shaylika Chauhan Rupak Desai 

机构地区：[1]Department of Medicine,ECU Health Medical Center,Greenville,NC 27834,United States [2]Department of Medicine,Jacobi Medical Center/Albert Einstein College of Medicine,Bronx,NY 10461,United States [3]Department of Medicine,North Alabama Medical Centre,Florence,AL 35630,United States [4]Department of General Medicine,Gandhi Medical College,Secunderabad 500003,Telangana,India [5]Department of Medicine,Government Medical College,Patiala 147001,Punjab,India [6]Department of Medicine,B.J.Medical College,Ahmedabad 380016,Gujarat,India [7]Department of Medicine,JSS Medical College,Mysore 570015,Karnataka,India [8]Department of Internal Medicine,Gandhi Medical College,Secunderabad 500003,Telangana,India [9]Department of Medicine,Kasturba Medical College,Manipal 575001,Karnataka,India [10]Clinical Extern,Department of Internal Medicine,Beaumont Hospital,Dearborn,MI 48124,United States [11]Department of Internal Medicine,Geisinger Health System,Wilkes-Barre,PA 18702,United States [12]Independent Researcher,Atlanta,GA 30079,United States

出　　处：《World Journal of Hepatology》2024年第6期912-919,共8页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular diseases independently of other risk factors.However,data on its effect on cardiovascular outcomes in coronavirus disease 2019(COVID-19)hospitalizations with varied obesity levels is scarce.Clinical management and patient care depend on understanding COVID-19 admission results in NAFLD patients with varying obesity levels.AIM To study the in-hospital outcomes in COVID-19 patients with NAFLD by severity of obesity.METHODS COVID-19 hospitalizations with NAFLD were identified using International Classification of Disease-10 CM codes in the 2020 National Inpatient Sample database.Overweight and Obesity Classes Ⅰ,Ⅱ,and Ⅲ(body mass index 30-40)were compared.Major adverse cardiac and cerebrovascular events(MACCE)(all-cause mortality,acute myocardial infarction,cardiac arrest,and stroke)were compared between groups.Multivariable regression analyses adjusted for sociodemographic,hospitalization features,and comorbidities.RESULTS Our analysis comprised 13260 hospitalizations,7.3% of which were overweight,24.3% Class Ⅰ,24.1% Class Ⅱ,and 44.3% Class Ⅲ.Class Ⅲ obesity includes younger patients,blacks,females,diabetics,and hypertensive patients.On multivariable logistic analysis,Class Ⅲ obese patients had higher risks of MACCE,inpatient mortality,and respiratory failure than Class Ⅰ obese patients.Class Ⅱ obesity showed increased risks of MACCE,inpatient mortality,and respiratory failure than Class I,but not significantly.All obesity classes had non-significant risks of MACCE,inpatient mortality,and respiratory failure compared to the overweight group.CONCLUSION Class Ⅲ obese NAFLD COVID-19 patients had a greater risk of adverse outcomes than class Ⅰ.Using the overweight group as the reference,unfavorable outcomes were not significantly different.Morbid obesity had a greater risk of MACCE regardless of the referent group(overweight or Class Ⅰ obese)compared to overweight NAFLD patients admitted with COVID-19.

关 键 词：Non-alcoholic fatty liver disease OBESITY OBESE Body mass index Major adverse cardiac and cerebrovascular events Mortality Acute myocardial infarction Cardiac arrest Stroke 

分 类 号：R575.5[医药卫生—消化系统]