Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits  

作　　者：Xi Chen Ya-Nan Zhou Xiao-Zi Lu Ren-Jiao Li Yi-Fan Xiong Xia Sheng Wei-Wei Zhu 

机构地区：[1]Department of Child and Adolescent Psychiatric,Brain Hospital of Hunan Province,The Second People’s Hospital of Hunan Province,Changsha 410007,Hunan Province,China [2]Department of Psychiatry,Qingdao Mental Health Center,Qingdao 266034,Shandong Province,China [3]Department of Psychiatry,Brain Hospital of Hunan Province,The Second People’s Hospital of Hunan Province,Changsha 410007,Hunan Province,China [4]Department of Sleep Disorders and Neurosis,Brain Hospital of Hunan Province,The Second People’s Hospital of Hunan Province,Changsha 410007,Hunan Province,China

出　　处：《World Journal of Psychiatry》2024年第6期784-793,共10页世界精神病学杂志

摘　　要：BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and behavior.AIM To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective treatments.METHODS This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same period.The expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance spectroscopy.The recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive function.The correlation between GABA receptor subunit downregulation and schizophrenia was also analyzed.RESULTS Significant differences in GABA receptor subunit levels were found between the case and control groups(P<0.05).A significant difference was also found between the case and control groups in terms of cognitive function measures,including attention/alertness and learning ability(P<0.05).Specifically,as the expression levels of GABRA1(α1 subunit gene),GABRB2(β2 subunit gene),GABRD(δsubunit),and GABRE(εsubunit)decreased,the severity of the patients’condition increased gradually,indicating a positive correlation between the downregulation of these 4 receptor subunits and schizophrenia(P<0.05).However,the expression levels of GABRA5(α5 subunit gene)and GABRA6(α6 subunit gene)showed no significant correlation with schizophrenia(P>0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with schizophrenia.In other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关 键 词：Cognitive function SCHIZOPHRENIA DOWNREGULATION Gamma-aminobutyric acid receptor subunits CORRELATION 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]