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Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells
《Oncology Research》2025年第5期1161-1172,共12页CHENXIAO QIAO YIPENG XU YEDIE HE ZHIJIAN CAI HUA WANG 
supported by Techpool Bio-Pharma Co.,Ltd.(grant no.AKR-S005).
Objective:To investigate the anti-tumor effects of an E1B55KD-deleted oncolytic adenovirus,H101,in combination with a humanized anti-PD-1(Programmed cell death protein 1)monoclonal antibody,Camrelizumab.Methods:Anti-t...
关键词：Cancer Oncolytic adenovirus Macrophage CD47 Programmed cell death protein 1 blockade(PD-1 blockade) 
MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B
《World Journal of Diabetes》2025年第4期189-204,共16页Ying Yang Yi Chen Jian-Ying Tang Jian Chen Gui-Qing Li Bing Feng Jiao Mu 
Supported by the Chongqing Basic Research and Frontier Exploration Project,No.cstc2018jcyjAX0834.
BACKGROUND At present,the incidence of diabetic nephropathy is increasing year by year,and there are many studies on the pathogenesis of diabetic nephropathy,but it is still not completely clear.The final pathological...
关键词：Diabetic kidney disease Mir-29a-3p DNA methylation Janus kinase/signal transducer and activator of transcription WNT/Β-CATENIN Renal fibrosis 
Downregulation of huntingtin-associated protein 1 predicts poor prognosis in gastric cancer
《World Journal of Clinical Oncology》2025年第4期186-194,共9页Xiang-Yang Wang Fu-Hai Yang Zhong-Yuan Yuan Zhong-Jing Wang Hong-Feng Zhang Zi-Hui Xu 
Supported by the Hubei Province Natural Science Foundation Project,No.2021CFB448;the Wuhan Municipal Health Commission,No.WX23A55.
BACKGROUND Highly expressed in the gastrointestinal mucosa,huntingtin-associated protein 1(HAP1)is closely associated with tumor development and prognosis.AIM To investigate the clinical utility of HAP1 expression in ...
关键词：Huntingtin-associated protein 1 Gastric cancer Prognostic utility BIOMARKER Clinical stage 
Hepatic-specific vitamin D receptor downregulation alleviates agingrelated metabolic dysfunction-associated steatotic liver disease
《World Journal of Gastroenterology》2025年第14期118-141,共24页Feng Zhu Bing-Ru Lin Shi-Hua Lin Chao-Hui Yu Yun-Mei Yang 
Supported by the National Natural Science Foundation of China,No.820300089.
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is defined by the abnormal lipid deposition in hepatocytes.The prevalence of MASLD is significantly increased in the elderly population,suggest...
关键词：Aging Metabolic dysfunction-associated steatotic liver disease Vitamin D receptor STEATOSIS HEPATOCYTES 
Decreased basal thermogenesis is associated with the downregulation of cellular metabolic activity of organs and serum thyroid hormones in fasting Eurasian Tree Sparrows(Passer montanus)
《Avian Research》2025年第1期39-52,共14页Hong Jin Qi Xia Ziqing Gao Yujie XuanYuan Beibei Dong Ming Li Qingjian Liang Jinsong Liu 
financially supported by grants from the National Natural Science Foundation of China (Nos.32371573,32171497,and 31971420)。
Food is a critical environmental factor that influences animal survival,especially for small passerines due to their high mass-specific metabolic rates.Basal metabolic rate(BMR)reflects the energy expended by endother...
关键词：Basal metabolic rate Energy metabolism FASTING Passer montanus Thyroid hormones av-UCPmRNA 
Carrier-adjuvanted immunostimulator to boost photodynamicimmunotherapy by downregulating PD-L1 and impairing ATP hydrolysis
《Science China Materials》2025年第2期626-639,共14页Yi Cen Ying Chen Hua Cai Xinxuan Li Xiayun Chen Qianqian Liu Baixue Yu Yibin Liu Tao Wang Shiying Li 
financially supported by the National Key R&D Program of China (2021YFD1800600);the National Natural Science Foundation of China (32371394);the Open Research Foundation of State Key Laboratory of Respiratory Diseases (SKLRD-OP-202204)。
Immune evasion behavior and immunosuppressive characteristics of tumor extensively impedethe immune initiation effect of therapy triggered immunogeniccell death (ICD). In this work, a carrier-adjuvantedimmunostimulato...
关键词：photodynamic therapy PD-L1 downregulation immunogenic cell death CD39 antitumor immunity 
Bioinformatics analysis of the association between miR-942-5p–induced downregulation of PIEZO-type mechanosensitive ion channel component 1 and poor prognosis in non–small cell lung cancer mediated by the mitogen-activated protein kinase pathway signaling pathway
《Oncology and Translational Medicine》2024年第6期272-280,共9页Lingdi Duan Min Zhao Hongquan Wei Wei Dong Xiaomin Bi Lin Ang Shan Zhang 
supported by grants from the Hefei Municipal Health Commission Applied Medical Research Project(no.Hwk2021yb012);Hefei Municipal Health Commission Applied Medical Research Project(no.Hwk2023zd007).
Background:Non–small cell lung cancer(NSCLC)is a common malignant tumor with an increasing incidence.PIEZO-type mechanosensitive ion channel component 1(PIEZO1)is a mechanosensitive ion channel whose expression has b...
关键词：Non–small cell lung cancer PIEZO1 BIOINFORMATICS MAPK MiR-942-5p 
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB
《Signal Transduction and Targeted Therapy》2024年第11期5267-5285,共19页Xiujian Wang Xiao Tao Pengjie Chen Penglei Jiang Wenxiao Li Hefeng Chang Cong Wei Xinyi Lai Hao Zhang Yihan Pan Lijuan Ding Zuyu Liang Jiazhen Cui Mi Shao Xinyi Teng Tianning Gu Jieping Wei Delin Kong Xiaohui Si Yingli Han Huarui Fu Yu Lin Jian Yu Xia Li Dongrui Wang Yongxian Hu Pengxu Qian He Huang 
supported by the National Key Research and Development Program of China(2022YFA1103500 to P.Q.);the National Key Nature Science Foundation of China(82130003 to H.H.);the Key Project of Science and Technology Department of Zhejiang Province(2019C03016 and 2020C03G2013586 to H.H.,Z24H080001 to P.Q.);the National Natural Science Foundation of China(82200248 and 82000194 to H.H.,82222003 and 82161138028 to P.Q.);the Key R&D Program of Zhejiang(2024SSYS0023 to H.H.,2024SSYS0024 to P.Q.,2024SSYS0025 to Y.H.);the Fundamental Research Funds for the Central Universities(226-2024-00007 to P.Q.).
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T(CAR-T)cells.MEK1/2 inhibitors(MEKIs),widely...
关键词：JUNB metabolism STIMULATION 
Retraction:Downregulation of microRNA-135 promotes sensitivity of non-small cell lung cancer to gefitinib by targeting TRIM16
《Oncology Research》2024年第11期1813-1813,共1页Oncology Research Editorial Office 
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
关键词：raised concerned SHAPED 
Retraction:Ailanthone promotes human vestibular schwannoma cell apoptosis and autophagy by downregulation of miR-21
《Oncology Research》2024年第11期1811-1811,共1页Oncology Research Editorial Office 
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
关键词：raised concerned shaped 
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