Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene:Hypotheses and conundrums  

作　　者：Zhi-Xin Xie Yue Li Ai-Ming Yang Dong Wu Qiang Wang 

机构地区：[1]State Key Laboratory of Complex Severe and Rare Diseases,Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China [2]Department of Clinical Medicine,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China

出　　处：《World Journal of Gastroenterology》2024年第19期2505-2511,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by the National High-Level Hospital Clinical Research Fund,No.2022-PUMCH-A-020;the Undergraduate Teaching Reform and Innovation Project,No.2022zlgc0108.

摘　　要：Chronic enteropathy associated with the SLCO2A1 gene(CEAS)is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss.This review explores the potential mechanisms underlying the pathogenesis of CEAS,focusing on the role of SLCO2A1-encoded prostaglandin transporter OATP2A1 and its impact on prostaglandin E2(PGE2)levels.Studies have suggested that elevated PGE2 levels contribute to mucosal damage,inflammation,and disruption of the intestinal barrier.The effects of PGE2 on macrophage activation and Maxi-Cl channel functionality,as well as its interaction with nonsteroidal anti-inflammatory drugs play crucial roles in the progression of CEAS.Understanding the balance between its protective and pro-inflammatory effects and the complex interactions within the gastrointestinal tract can shed light on potential therapeutic targets for CEAS and guide the development of novel,targeted therapies.

关 键 词：SLCO2A1 Prostaglandin E2 Chronic enteropathy associated with the SLCO2A1 gene Small intestine MACROPHAGE 

分 类 号：R574[医药卫生—消化系统]