Close relationship between mediators of inflammation and pancreatic cancer:Our experience  

作　　者：Francesca Vescio Michele Ammendola Giuseppe Currò Silvia Curcio 

机构地区：[1]Department,General Surgery Unit,University“Magna Graecia”Medical School,University Hospital“R.Dulbecco”,Catanzaro 88100,Italy [2]Science of Health Department,Digestive Surgery Unit,University“Magna Graecia”Medical School,University Hospital“R.Dulbecco”,Catanzaro 88100,Italy

出　　处：《World Journal of Gastroenterology》2024年第23期2927-2930,共4页世界胃肠病学杂志（英文版）

摘　　要：In this editorial,we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic cancer.Cancer of the pancreas remains one of the deadliest cancer types.The highest incidence and mortality rates of pancreatic cancer are found in developed countries.Trends of pancreatic cancer incidence and mortality vary considerably worldwide.A better understanding of the etiology and identification of the risk factors is essential for the primary prevention of this disease.Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche.In this editorial,we highlight the foundational studies that have driven our understanding of these processes.In our experimental center,we have carefully studied the mechanisms of that link pancreatic inflammation and pancreatic cancer.We focused on the role of mast cells(MCs).MCs contain pro-angiogenic factors,including tryptase,that are associated with increased angiogenesis in various tumors.In this editorial,we address the role of MCs in angiogenesis in both pancreatic ductal adenocarcinoma tissue and adjacent normal tissue.The assessment includes the density of c-Kit receptor-positive MCs,the density of tryptase-positive MCs,the area of tryptasepositive MCs,and angiogenesis in terms of microvascularization density.

关 键 词：Mast cells C-Kit receptor TRYPTASE Angiogenesis Microvascular density Endothelial area Pancreatic tumor tissue Adjacent normal tissue 

分 类 号：R735.9[医药卫生—肿瘤]