Tilapia Head Glycolipid Alleviates Indomethacin-Induced Gastric Ulcer via Regulating Oxidative Stress and Inflammation Through COX/PGE2 Signaling Pathway in Adult Rats  

作　　者：WANG Bohui WU Haixing SHAO Mingyang JIANG Mengqi SU Ruiheng GAO Xia XIA Guanghua SHI Haohao SHEN Xuanri 

机构地区：[1]Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea,College of Food Science and Technology,Hainan University,Haikou 570228,China [2]Collaborative Innovation Center of Marine Food Deep Processing,Dalian Polytechnic University,Dalian 116000,China [3]College of Food and Engineering,Hainan Tropical Ocean University,Sanya 572022,China

出　　处：《Journal of Ocean University of China》2024年第3期743-754,共12页中国海洋大学学报（英文版）

基　　金：supported by the National Key R&D Pro-grams of China(No.2018YFD0901103);the Hainan Provincial Natural Science Foundation of China(No.2019 RC093).

摘　　要：The aim of this experiment was to investigate the ameliorative effect and molecular mechanism of tilapia head glycolipid(TH-GL)on indomethacin(IDM)-induced gastric ulcer in male Sprague Dawley(SD)rats.The gastric ulcer model was established by oral administration of 30mgkg^(-1) IDM after 7 days of TH-GL or omeprazole(OME)administration in rats.Then the macroscopic gastric injury symptoms,gastric mucosa protective factor cyclooxygenase 1(COX-1),cyclooxygenase 2(COX-2),prostaglandin E_(2)(PGE_(2)),the levels of oxidative stress,and inflammatory cytokine expression levels in the rats were analyzed.The experimental results showed that multiple ulcers appeared on the gastric surface of the rats in the model group.Compared to the model group,TH-GL significantly alleviated gastric ulcers and reduced the gastric damage index in rats.In addition,TH-GL significantly promoted the expression of constitutive enzyme COX-1 while inhibited the expression of inducible enzyme COX-2,and make PGE2 maintain at normal levels.TH-GL also inhibited oxidative stress and inflammatory responses,increased superoxide dismutase(SOD)activity and glutathione(GSH)content,decreased the level of malondialdehyde(MDA)and the content of pro-inflammatory factor.In conclusion,these results suggested that TH-GL could maintain the expression levels of COX-1 and PGE2 while inhibit the expression of COX-2 in the gastric of rat and then prevent IDM-induced gastric ulcer,which may be related to the regulation of oxidative stress and inflammatory response.Therefore,TH-GL might be a new option for the prevention of gastric diseases induced by IDM.

关 键 词：tilapia head glycolipid indomethacin gastric ulcer oxidative stress INFLAMMATION 

分 类 号：R573.1[医药卫生—消化系统] R-332[医药卫生—内科学]