Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis  

作　　者：Xin-tong JI Wen-lei YU Meng-jia JIN Lin-jie LU Hong-ping YIN Huan-huan WANG 

机构地区：[1]School of Basic Medical Sciences,Affiliated Hospital of Hangzhou Normal University,Hangzhou Normal University,Hangzhou 311121,China [2]School of Medicine,Chongqing University,Chongqing 400030,China [3]Department of Stomatology,Huzhou Wuxing District People's Hospital,Huzhou Wuxing District Maternal and Child Health Hospital,Huzhou 313008,China [4]School of Pharmacy,Zhejiang University,Hangzhou 310030,China [5]Department of Stomatology,Haining Hospital of Traditional Chinese Medicine,Jiaxing 314400,China

出　　处：《Current Medical Science》2024年第2期281-290,共10页当代医学科学（英文）

基　　金：supported by grants from Zhejiang Provincial Natural Science Foundation of China(No.LY19H260003);Zhejiang Medical Health Science and Technology Project of China(No.2024KY1661).

摘　　要：Recent studies have shown that cellular levels of polyamines(PAs)are significantly altered in neurodegenerative diseases.Evidence from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress,mitochondrial metabolism,cellular immunity,and ion channel functions.Dysfunction of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative diseases.Therefore,in the current work,evidence was collected to determine the possible associations between cellular levels of PAs,and related enzymes and the development of several neurodegenerative diseases,which could provide a new idea for the treatment of neurodegenerative diseases in the future.

关 键 词：POLYAMINE APOPTOSIS MITOCHONDRIA neurodegenerative disease 

分 类 号：R338[医药卫生—人体生理学]