儿童期精神分裂症的遗传特点研究进展  

Advances in the genetic characterization of childhood-onset schizophrenia

作　　者：孙志刚[1] 贾美香[2] 薛曼[1] 李素水[1] 郭年春[1] UN Zhi-gang;JIA Mei-xiang;XUE Man;LI Su-shui;GUO Nian-chun(The Eighth Hospital of Shijiazhuang City,Shijiazhuang 050081,China)

机构地区：[1]石家庄市第八医院,050000 [2]北京大学第六医院

出　　处：《临床精神医学杂志》2024年第3期245-248,共4页Journal of Clinical Psychiatry

基　　金：河北省高层次人才资助项目(A2016002087);河北省科技计划项目(152777223);石家庄市科技计划项目(231460033A)。

摘　　要：本文综述了儿童期精神分裂症(COS)的遗传特点,COS遗传度>80%,主要表现为(1)相关风险基因与成年期精神分裂症有很多重叠;(2)很多风险基因也关联孤独症谱系障碍等更早发的神经发育性障碍;(3)COS的风险基因结构中含有更多的常见和罕见变异体,包括拷贝数变异体(CNVs)。This article summarized the genetic characteristics of childhood onset schizophrenia(COS).The heritability of COS was over 80%,which showed that①relevant risk genes overlaps with adult schizophrenia.②Many risk genes are also associated with earlier neurodevelopmental disorders such as autism spectrum disorder;③The risk gene structure of COS contains more common and rare variants,including copy number variants.

关 键 词：儿童期精神分裂症 遗传学 常见变异体 罕见变异体 

分 类 号：R749.3[医药卫生—神经病学与精神病学]