肺癌组织中PD-L1与dMMR相关蛋白表达的关系及其临床意义  

The Relationship Between the Expression of PD-L1 and dMMR Related Proteins in Lung Cancer and Its Clinical Significance

作　　者：沈艳丽 李金金 陈献亮 SHEN Yanli;LI Jinjin;CHEN Xianliang(Fuwai Huazhong Cardiovascular Hospital,Zhengzhou,451464)

机构地区：[1]阜外华中心血管病医院,451464

出　　处：《实用癌症杂志》2024年第6期895-897,920,共4页The Practical Journal of Cancer

摘　　要：目的探讨肺癌组织中PD-L1与dMMR相关蛋白表达的关系及其临床意义。方法收集行肺部根治手术且均确诊为肺癌患者石蜡标本71例(癌组织、癌旁组织)及其相关临床资料。采用免疫组织化学染色法检测癌组织和癌旁组织中PD-L1、dMMR相关蛋白的表达情况及临床意义。结果肺癌组织PD-L1、dMMR相关蛋白阳性表达均高于癌旁组织,P<0.05。PD-L1表达与肺癌患者T分期、TNM分期有关(P<0.05),与性别、年龄、N分期无关(P>0.05)。dMMR相关蛋白表达与肺癌患者TNM分期有关(P<0.05),与性别、年龄、T分期、N分期无关(P>0.05)。PD-L1表达与dMMR呈明显正相关性(γ=0.296,P=0.022)。将患者分为复发组和未复发组,多因素Logistic回归分析发现PD-L1是复发的危险因素(P<0.05),而dMMR并不是复发的危险因素(P>0.05)。结论PD-L1及dMMR相关蛋白在肺癌中具有高表达,其中PD-L1为肿瘤复发的风险因素。Objective To investigate the relationship between the expression of PD-L1 and dMMR related proteins in lung cancer tissues and its clinical significance.Methods Paraffin specimens(cancer tissue,adjacent tissue)and related clinical data were collected from 71 patients diagnosed with lung cancer after radical lung resection.Immunohistochemical staining was used to detect the expression of PD-L1 and dMMR related proteins in cancer tissues and adjacent tissues and their clinical significance.Results The positive expressions of PD-L1 and dMMR related proteins in lung cancer tissues were higher than those in adjacent tissues(P<0.05).The expression of PD-L1 was correlated with T stage and TNM stage of lung cancer patients(P<0.05),but not with gender,age or N stage(P>0.05).The expression of dMMR related protein was correlated with TNM stage of lung cancer patients(P<0.05),but not with sex,age,T stage or N stage(P>0.05).The expression of PD-L1 was positively correlated with dMMR(γ=0.296,P=0.022).The patients were divided into recurrence group and non-recurrence group.Multivariate Logistic regression analysis found that PD-L1 was a risk factor for recurrence,P<0.05,while dMMR was not a risk factor for recurrence,P>0.05.Conclusion PD-L1 and dMMR related proteins are highly expressed in lung cancer,and PD-L1 is a risk factor for tumor recurrence.

关 键 词：肺癌 PD-L1 dMMR 复发 预后 

分 类 号：R734.2[医药卫生—肿瘤]