Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice  

作　　者：Dan Yi Hongting Jin William W.Lu Chunxiang Zhang Guozhi Xiao Liping Tonag Di Chen 

机构地区：[1]Research Center for Computer-aided Drug Discovery,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,China [2]PFaculty of Pharmaceutical Sciences,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,China [3]The First College of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China [4]Department of Cardiology,Basic Medicine Innovation Centerfor Cardiometabolic Diseases of Ministry of Education,Institute of Cardiovascular Research,The Affiliated Hospital,Southwest Medical University,Luzhou,Sichuan 646000,China [5]School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China

出　　处：《Genes & Diseases》2024年第4期149-151,共3页基因与疾病（英文）

基　　金：funded by the National Key Research and Development Program of China(No.2021YFB3800800)to LT and DC;the National Natural Science Foundation of China(NSFC,No.82030067,82161160342,82250710174)to DC;the Hong Kong RGC grant(China)(HKU-17101821)to WWL and DC.

摘　　要：In mammals,skeletal bone development begins at hyaline cartilage formation at the early embryonic stage.1Then osteoblasts from the periosteum,which are distributed surrounding the hyaline cartilage,build up compact bone to formdiaphysis and spongy bone known as primary ossification center.1 Next,osteoclasts from the hematopoietic system destroy spongy bone to generate a medullary cavity.

关 键 词：CARTILAGE SKELETAL MEDULLARY 

分 类 号：R68[医药卫生—骨科学]