人类衰竭心脏中髓系细胞的全面描述  

Global characterization of myeloid cells in the human failing heart

作　　者：张思 唐婷婷 朱亦橙 张绪哲 刘金平 蔡杰 张凌雪 夏霓 聂少芳 张敏 朱争凤 胡德胜 王维民 张丽 廖玉华 董念国 程翔 Si Zhang;Tingting Tang;Yicheng Zhu;Xuzhe Zhang;Jinping Liu;Jie Cai;Lingxue Zhang;Ni Xia;Shaofang Nie;Min Zhang;Zhengfeng Zhu;Desheng Hu;Weimin Wang;Li Zhang;Yuhua Liao;Nianguo Dong;Xiang Cheng(Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Key Laboratory of Biological Targeted Therapy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Cardiovascular Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Immunology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Ultrasound,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [2]Hubei Key Laboratory of Biological Targeted Therapy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [3]Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [4]Department of Cardiovascular Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [5]Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [6]Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [7]Department of Immunology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [8]Department of Ultrasound,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

出　　处：《Science Bulletin》2024年第10期1380-1385,共6页科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(82030016,82230011,82170394,82300447 and 82170282);the Department of Science and Technology of Hubei Province(2023AFA113).

摘　　要：Heart failure(HF)remains a rising global epidemic worldwide[1,2].It is widely recognized that immune cells play important roles in the pathogenesis of HF.The hearts of HF patients are characterized by persistent low-grade inflammation,which has been linked to adverse ventricular remodeling as it promotes interstitial fibrosis and cardiomyocyte dysfunction and loss.

关 键 词：衰竭心脏 髓系细胞 INFLAMMATION 

分 类 号：R541.6[医药卫生—心血管疾病]