Antioxidant treatment for oligoasthenoteratozoospermia and varicocele:a DBPC trial to evaluate the impact of age and body mass index  

作　　者：Gian Maria Busetto Bernarde F Rodrigues Ashraf Virmani Andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri Piero Fischetti Ugo G Falagario Pasquale Annese Nicola d’Altilia Vito Mancini Matteo Ferro Felice Crocetto Angelo Porreca Carlo Bettocchi Luigi Cormio Ashok Agarwal Giuseppe Carrieri 

机构地区：[1]University of Foggia,Foggia 71122,Italy [2]Department of Urology and Renal Transplantation,Policlinico of Foggia,Foggia 71122,Italy [3]Department of Urology,Human Reproduction Section,Federal University of Sao Paulo,Sao Paulo 05403-000,Brazil [4]Alfasigma Healthscience,Utrecht 3528 BG,The Netherlands [5]Urology Unit,“G.Tatarella”Hospital,Cerignola 71042,Italy [6]Urology Unit,European Institute of Oncology(IEO)IRCCS,Milan 20142,Italy [7]University of Naples Federico II,Naples80126,Italy [8]Department of Oncological Urology,Veneto Institute of Oncology(IOV)IRCCS,Padua 35039,Italy [9]Urology Unit,“L.Bonomo”Hospital,Andria 70031,Italy [10]Global Andrology Forum,Moreland Hills,OH 44022,USA

出　　处：《Asian Journal of Andrology》2024年第3期239-244,共6页亚洲男性学杂志（英文版）

摘　　要：Oxidative stress is one of the main mechanisms responsible for male infertility.Various conditions such as varicocele,obesity,advanced age,and lifestyle can lead to an increase in reactive oxygen species,causing an oxidative imbalance in the reproductiveenvironment.Spermatozoa are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizingthe egg.Excessive reactive oxygen species can affect sperm metabolism,leading to immobility,impaired acrosome reaction,and celldeath,thereby impairing reproductive success.This double-blind randomized study evaluated the effect of supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and other nutrients on semen quality in 104 infertile patients with or without varicocele,while also investigating the impact of factors such as obesity and advanced age on treatment.Sperm concentration significantlyincreased in the supplemented group compared to the placebo group(P=0.0186).Total sperm count also significantly increasedin the supplemented group(P=0.0117),as did sperm motility(P=0.0120).The treatment had a positive effect on patients upto 35 years of age in terms of sperm concentration(P=0.0352),while a body mass index(BMI)above 25 kg m^(−2) had a negativeeffect on sperm concentration(P=0.0110).Results were not showing a net benefit in stratifying patients in accordance withtheir BMI since sperm quality increase was not affected by this parameter.In conclusion,antioxidant supplementation may bebeneficial for infertile patients and has a more positive effect on younger patients with a normal weight.

关 键 词：AGING ANTIOXIDANTS body mass index OLIGOASTHENOTERATOZOOSPERMIA VARICOCELE 

分 类 号：R698.2[医药卫生—泌尿科学]