Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Ca_(v)2.1 channels  

作　　者：Zhangqiang Li Ye Cong Tong Wu Tongtong Wang Xinyao Lou Xinyu Yang Nieng Yan 

机构地区：[1]Beijing Frontier Research Center for Biological Structures,State Key Laboratory of Membrane Biology,Tsinghua-Peking Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing,China [2]Institute of Bio-Architecture and Bio-Interactions,Shenzhen Medical Academy of Research and Translation,Shenzhen,Guangdong,China

出　　处：《Cell Research》2024年第6期455-457,共3页细胞研究（英文版）

基　　金：funded by the National Natural Science Foundation of China(32330052).

摘　　要：Dear Editor,Voltage-gated calcium(Cav)channels are essential for mediating Ca^(2+) influx in response to membrane depolarization.Activation of Ca_(v) channels triggers fundamental physiological processes such as muscle contraction,neurotransmitter release,hormone secretion,and synaptic integration.^(1,2) The P/Q-type Ca_(v) channels Ca_(v)2.1,encoded by CACNA1A and prevalently found in neurons and neuroendocrine cells,play a vital role in the release of neurotransmitters and the regulation of synaptic plasticity and neuronal excitability.^(3) Ca_(v)2.1 presents a potential therapeutic target for treating neurological disorders,such as epilepsy and migraine.

关 键 词：EPILEPSY RELEASE MIGRAINE 

分 类 号：R741[医药卫生—神经病学与精神病学]