Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder  

作　　者：Jie Wang Wenfeng Zhao Huang Wang Haixia Leng Qing Xue Mao Peng Baoquan Min Xiukun Jin Liucen Tan Keming Gao Hongxing Wang 

机构地区：[1]Songjiang Hospital and Songjiang Research Institute,Shanghai Key Laboratory of Emotions and Affective Disorders,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Institute of Neuroscience and Brain Diseases,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang,Hubei,China [3]Division of Neuropsychiatry and Psychosomatics,Department of Neurology,Xuanwu Hospital of Capital Medical University,Beijing,China [4]Electroconvulsive Therapy,University Hospitals Cleveland Medical Center,Cleveland,Ohio,USA [5]Department of Psychiatry,Case Western Reserve University School of Medicine,Cleveland,Ohio,USA [6]Institute of Sleep and Consciousness Disorders,Center of Epilepsy,Beijing Institute for Brain Disorders,Capital Medical University,Beijing,China [7]Institute of Special Medical Sciences,School of Forensic Medicine,Shanxi Medical University,Taiyuan,Shanxi,China

出　　处：《General Psychiatry》2024年第2期265-273,共9页综合精神医学（英文）

基　　金：The study was partly funded by the National Natural Science Foundation of China(82371490);the National Key R&D Program of China(2022YFC2503900,2022YFC2503901);Beijing Hundred,Thousand and Ten Thousand Talents Project(2017-CXYF-09);Beijing Health System Leading Talent Grant(2022-02-10).

摘　　要：Background Although 15 mA transcranial alternating current stimulation(tACS)has a therapeutic effect on depression,the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA,delivered via the forehead and the mastoid electrodes in the human brain.Methods Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve,first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.Results The electric field distributions of the sagittal,coronal and axial planes showed that the bilateral frontal lobes,bilateral temporal lobes,hippocampus,cingulate,hypothalamus,thalamus,amygdala,cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Conclusions Brain-wide activation,including the cortex,subcortical structures,cerebellum and brainstem,is involved in the 15 mA tACS intervention for first-episode major depressive disorder.Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.

关 键 词：STIMULATION INVOLVEMENT ACTIVATION 

分 类 号：R749.4[医药卫生—神经病学与精神病学]