糖皮质激素性高眼压小梁网病理改变及相关分子机制进展  

Research progress on pathological changes and molecular mechanism of trabecular meshwork in glucocorticoid-induced ocular hypertension

作　　者：王佳佳[1] 张静琳 Wang Jiajia;Zhang Jinglin(Aier Eye Hospital,Jinan University,Guangzhou 510071,Guangdong Province,China)

机构地区：[1]暨南大学附属爱尔眼科医院,广东省广州市510071

出　　处：《国际眼科杂志》2024年第7期1088-1092,共5页International Eye Science

基　　金：湖南省自然科学基金项目(No.2023JJ70049);广州市科技计划项目(No.2022010200752)。

摘　　要：糖皮质激素性高眼压(GIOH)是一种由糖皮质激素引起的高眼压。长期处于GIOH状态,可能会导致视神经损害和视野缺损,最终发展成糖皮质激素性青光眼(GIG),可能致盲。糖皮质激素主要通过介导糖皮质激素受体(GR)发挥生物学作用,同时还涉及到转化生长因子(TGF)-β、Wnt、Rho等因素在GIOH的形成中的作用。深入探讨GIOH小梁网的病理改变及相关分子机制对于理解GIOH的发病机制和治疗提供了重要的理论依据。因此文章就GIOH小梁网的病理改变及相关分子机制进行综述,旨在为进一步研究GIOH的病理机制及治疗提供理论依据。Glucocorticoid-induced ocular hypertension(GIOH)is a condition characterized by elevated intraocular pressure caused by glucocorticoids.The long-term presence of GIOH may lead to optic nerve damage and visual field defects,eventually progressing to glucocorticoid-induced glaucoma(GIG),which can potentially cause blindness.Glucocorticoids primarily exert their biological effects by mediating glucocorticoid receptor(GR),while also involving factors such as transforming growth factor(TGF)-β,Wnt,and Rho in the formation of GIOH.In-depth exploration of the pathological changes and related molecular mechanisms of the trabecular meshwork in GIOH provides an important theoretical basis for understanding the pathogenesis and treatment of GIOH.Therefore,this article provides a review of the pathological changes and molecular mechanisms of the trabecular meshwork in GIOH,aiming to provide a theoretical basis for further research on the pathological mechanisms and treatment of GIOH.

关 键 词：糖皮质激素 高眼压 青光眼 小梁网 分子机制 

分 类 号：R775[医药卫生—眼科]