外用含牛乳护肤霜治疗儿童寻常型鱼鳞病的临床疗效观察  

Auxiliary Effects of Topical Milk Containing Skincare Cream in Treating Children with Ichthyosis Vulgaris

作　　者：秦蓓 王莹[1] 陈立新[1] 李钦峰[1] Qin Bei;Wang Ying;Chen Lixin;Li Qinfeng(Tianjin Children′s Hospital(Children's Hospital of Tianjin University),Tianjin 300074,China)

机构地区：[1]天津市儿童医院(天津大学儿童医院),天津300074

出　　处：《中国中西医结合皮肤性病学杂志》2024年第3期221-224,共4页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：天津市卫生健康委员会科技项目(编号:ZC20062)。

摘　　要：目的探讨外用含牛乳护肤霜儿童寻常型鱼鳞病(IV)的作用。方法收集2022年11月—2023年4月就诊于天津市儿童医院皮肤科门诊的0.5~10.0岁的IV患儿78例,采用自身对照的研究设计,试验部位外用牛乳护肤霜治疗,每日2次,分别在入组第1天(D0),第14天(D14)进行无创皮肤参数测试及皮肤微生物取样。结果共入组IV患儿78例,实际完成55例。治疗14 d后2组患儿试验部位角质层含水量较治疗前增高(67.62±3.35比49.11±5.04,P<0.05),p H值较治疗前降低(4.94±0.36比5.94±0.18,P<0.05),弹性较治疗前增加(66.76±6.06比53.65±3.82,P<0.05),差异均有统计学意义;黑色素值治疗前后差异无统计学意义(P>0.05);皮损区菌群分布明显改善,菌群多样性增加,差异有统计学意义(P<0.05)。所有患儿均无明显异常感觉和局部感染出现,无严重不良反应发生。结论含牛乳护肤霜可有效缓解IV患儿的临床症状,修复皮肤屏障,有辅助治疗功效。Objective In order to explore the effects of topical milk containing skincare cream in treating children with ichthyosis vulgaris(IV).Methods A total of 78 children aged from 0.5 to 10.0 years old with IV who visited the dermatology outpatient department of Tianjin Children's Hospital from November 2022 to April 2023 were enrolled into the study.A self-control study design was used,and the experimental site was treated with milk containing skincare cream twice a day.Non invasive skin parameter tests and skin microbial sampling were conducted on the first day of enrollment(D0)and the 14th day(D14),respectively.Results A total of 78 children with IV were enrolled,and 55 cases were actually completed.After 14 days of treatment,the water content of the stratum corneum in the experimental site of children in both groups increased compared with before treatment(67.62±3.35 vs.49.11±5.04,P<0.05),the pH value decreased compared with before treatment(4.94±0.36 vs.5.94±0.18,P<0.05),the elasticity increased compared with before treatment(66.76±6.06 vs.53.65±3.82,P<0.05),the differences were statistically significant.There were no statistically significant differences in melanin values before and after treatment(P>0.05).The distribution of microbial communities in the lesion area had significantly improved,and the diversity of microbial communities increased,with statistical significance(P<0.05).All patients had no obvious sensory abnormalities,local infections,or serious adverse reactions.Conclusion Milk containing skincare cream can effectively alleviate the clinical symptoms of children with IV,repair the skin barrier,and have auxiliary therapeutic effects.

关 键 词：牛乳 寻常型鱼鳞病 皮肤屏障 

分 类 号：R758.52[医药卫生—皮肤病学与性病学]