Mechanism of Huanglian Detoxification Soup Relieving Postherpetic Neuralgia by Enhancing IL-2 Levels in Rats  

作　　者：Min YE Fengqin ZHANG Quiping YUAN Yong XIANG 

机构地区：[1]Department of Pain Treatment,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China

出　　处：《Medicinal Plant》2024年第3期39-40,共2页药用植物：英文版

摘　　要：[Objectives]To explore the mechanism of Huanglian detoxification soup improving pain behavior by affecting serum IL-2 levels in postherpetic neuralgia(post herpes neuralgia,PHN)model rats.[Methods]20 PHN rats were randomly divided into model group(PHN group)and detoxification decoction group(n=10).In the group,10%Huanglian detoxification soup(0.4 mL/0.1 kg)was given once in the morning and evening for 14 d.The PHN group was filled with an equal volume of 0.9%sodium chloride solution.Tail vein serum inflammatory factor interleukin-2(IL-2),IL-βand IL-6 levels were measured using ELISA kits at 7 and 21 d.[Results]IL-2 increased at 14 and 21 d in IL group,while IL-βand IL-6 decreased compared with the PHN group(P<0.05).[Conclusions]Huanglian detoxification soup may raise IL-2 levels after VZV infection to promote the differentiation of cells of the immune system,so as to relieve the pain caused by IL-βand IL-6 inflammatory factors.

关 键 词：Huanglian DETOXIFICATION SOUP Postherpetic NEURALGIA SERUM INFLAMMATORY factor 

分 类 号：R28[医药卫生—中药学]